U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cmoA carboxy-S-adenosyl-L-methionine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946380, updated on 17-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
cmoA
Official Full Name
carboxy-S-adenosyl-L-methionine synthase
Primary source
ECOCYC:G7020
Locus tag
b1870
See related
ASAP:ABE-0006237
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1871; yecO
Summary
CmoA catalyzes an intermediate step(s) in tRNA(cmo5U34) and tRNA(mcmo5U34) synthesis that forms uridine-5-oxyacetic acid (cmo5U) and uridine-5-oxyacetic acid methyl ester (mcmo5U) in tRNA. [More information is available at EcoGene: EG14033].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1952702..1953445)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene isochorismatase family protein YecD Neighboring gene DUF72 domain-containing protein YecE Neighboring gene MAPEG family inner membrane protein YecN Neighboring gene tRNA U34 carboxymethyltransferase Neighboring gene trimethylamine N-oxide reductase 2 Neighboring gene cytochrome c quinol dehydrogenase TorY

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine. Lim K, et al. Proteins, 2001 Dec 1. PMID 11746687
  2. S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA. Byrne RT, et al. Acta Crystallogr D Biol Crystallogr, 2013 Jun. PMID 23695253, Free PMC Article
  3. On the biosynthesis of 5-methoxyuridine and uridine-5-oxyacetic acid in specific procaryotic transfer RNAs. Murao K, et al. Nucleic Acids Res, 1978 Apr. PMID 418384, Free PMC Article
  4. Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases. Feder M, et al. Gene, 2003 Jan 2. PMID 12527203
  5. A method for isolation of Escherichia coli mutants with aberrant RNA methylation using translocatable drug resistance elements. Björk GR, et al. Acta Chem Scand B, 1979. PMID 93836

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding IEA
Inferred from Electronic Annotation
more info
  
enables carboxyl- or carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
carboxy-S-adenosyl-L-methionine synthase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1952702..1953445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416384.1 carboxy-S-adenosyl-L-methionine synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416384.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376K6I2, A0A5B9AJ69
    Conserved Domains (1) summary
    TIGR00740
    Location:4 → 242
    TIGR00740; tRNA (cmo5U34)-methyltransferase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.