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flhA flagellar biosynthesis protein FlhA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946390, updated on 3-Dec-2024

Summary

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Official Symbol
flhA
Official Full Name
flagellar biosynthesis protein FlhA
Primary source
ECOCYC:G370
Locus tag
b1879
See related
ASAP:ABE-0006272
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1880; flaH
Summary
Flagellar regulon. [More information is available at EcoGene: EG14273]. FlhA is one of six integral membrane components of the flagellar export apparatus. [More information is available at EcoCyc: G370].
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Genomic context

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Sequence:
NC_000913.3 (1962972..1965050, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YecT Neighboring gene flagellar protein FlhE Neighboring gene flagellar biosynthesis protein FlhB Neighboring gene chemotaxis protein CheZ Neighboring gene chemotaxis protein CheY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray analysis of the C-terminal cytoplasmic domain of FlhA, a membrane-protein subunit of the bacterial flagellar type III protein-export apparatus. Saijo-Hamano Y, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Jun 1. PMID 16511106, Free PMC Article
  2. FliK-Driven Conformational Rearrangements of FlhA and FlhB Are Required for Export Switching of the Flagellar Protein Export Apparatus. Minamino T, et al. J Bacteriol, 2020 Jan 15. PMID 31712281, Free PMC Article
  3. Assembly and stability of flagellar motor in Escherichia coli. Li H, et al. Mol Microbiol, 2011 May. PMID 21244534
  4. Incomplete flagellar structures in Escherichia coli mutants. Suzuki T, et al. J Bacteriol, 1981 Feb. PMID 7007337, Free PMC Article
  5. Flagella-Driven Motility of Bacteria. Nakamura S, et al. Biomolecules, 2019 Jul 14. PMID 31337100, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FliK-Driven Conformational Rearrangements of FlhA and FlhB Are Required for Export Switching of the Flagellar Protein Export Apparatus.
    Title: FliK-Driven Conformational Rearrangements of FlhA and FlhB Are Required for Export Switching of the Flagellar Protein Export Apparatus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in bacterial-type flagellum assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bacterial-type flagellum assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bacterial-type flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bacterial-type flagellum organization IEA
Inferred from Electronic Annotation
more info
  
involved_in bacterial-type flagellum-dependent cell motility NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chemotaxis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein secretion by the type III secretion system NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in bacterial-type flagellum NAS
Non-traceable Author Statement
more info
 PubMed 
located_in bacterial-type flagellum secretion apparatus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of type III protein secretion system complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
flagellar biosynthesis protein FlhA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1962972..1965050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416393.1 flagellar biosynthesis protein FlhA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416393.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8H9XP28, A0A8S7TBJ8
    Conserved Domains (1) summary
    PRK06012
    Location:2 → 691
    flhA; flagellar type III secretion system protein FlhA
Nucleotide Protein
Heading Accession and Version

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