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cheR chemotaxis protein methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946396, updated on 3-Dec-2024

Summary

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Official Symbol
cheR
Official Full Name
chemotaxis protein methyltransferase
Primary source
ECOCYC:EG10148
Locus tag
b1884
See related
ASAP:ABE-0006286
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cheX; ECK1885
Summary
Overexpression causes filamentous biofilm formation. otherPDB (S .typhimurium): [More information is available at EcoGene: EG10148]. CheR is a component of the adaptation pathway of the chemotaxis sensory transduction system of Escherichia coli. [More information is available at EcoCyc: EG10148].
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Genomic context

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Sequence:
NC_000913.3 (1968504..1969364, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene chemotaxis protein CheY Neighboring gene protein-glutamate methylesterase/protein glutamine deamidase Neighboring gene methyl-accepting chemotaxis protein Tap Neighboring gene methyl-accepting chemotaxis protein Tar

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Failure of sensory adaptation in bacterial mutants that are defective in a protein methylation reaction. Goy MF, et al. Cell, 1978 Dec. PMID 365357
  2. E. coli superdiffusion and chemotaxis-search strategy, precision, and motility. Matthäus F, et al. Biophys J, 2009 Aug 19. PMID 19686641, Free PMC Article
  3. Molecular modeling of flexible arm-mediated interactions between bacterial chemoreceptors and their modification enzyme. Muppirala UK, et al. Protein Sci, 2009 Aug. PMID 19606502, Free PMC Article
  4. Dual recognition of the bacterial chemoreceptor by chemotaxis-specific domains of the CheR methyltransferase. Shiomi D, et al. J Biol Chem, 2002 Nov 1. PMID 12101179
  5. The receptor docking segment and S-adenosyl-L-homocysteine bind independently to the methyltransferase of bacterial chemotaxis. Yi X, et al. Biochim Biophys Acta, 2002 Apr 1. PMID 11983418

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The exchange of CheB and CheR at receptor clusters shows a strong dependency on the receptor modification.
    Title: Effects of receptor modification and temperature on dynamics of sensory complexes in Escherichia coli chemotaxis.
  2. These studies revealed that the chemotactic response in swimming bacteria is fined-tuned to wild-type level of the [CheR]/[CheB] ratio.
    Title: Fine-tuning of chemotactic response in E. coli determined by high-throughput capillary assay.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-glutamate O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glutamate O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein methylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of methyl accepting chemotaxis protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of methyl accepting chemotaxis protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chemotaxis protein methyltransferase
NP_416398.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1968504..1969364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416398.1 chemotaxis protein methyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416398.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M6T2
    Conserved Domains (1) summary
    PRK10611
    Location:1 → 286
    PRK10611; protein-glutamate O-methyltransferase CheR
Nucleotide Protein
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