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cheW chemotaxis protein CheW [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946400, updated on 26-Nov-2024

Summary

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Official Symbol
cheW
Official Full Name
chemotaxis protein CheW
Primary source
ECOCYC:EG10149
Locus tag
b1887
See related
ASAP:ABE-0006292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1888
Summary
Flagellar regulon. [More information is available at EcoGene: EG10149]. CheW is involved in the transmission of sensory signals from the methyl-accepting chemotaxis proteins (MCPs) to the flagellar motors. [More information is available at EcoCyc: EG10149].
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Genomic context

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Sequence:
NC_000913.3 (1972836..1973339, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene methyl-accepting chemotaxis protein Tap Neighboring gene methyl-accepting chemotaxis protein Tar Neighboring gene chemotaxis protein CheA Neighboring gene motility protein B Neighboring gene motility protein A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of the CheW protein in bacterial chemotaxis: overexpression is equivalent to absence. Sanders DA, et al. J Bacteriol, 1989 Nov. PMID 2681160, Free PMC Article
  2. Signalling-dependent interactions between the kinase-coupling protein CheW and chemoreceptors in living cells. Pedetta A, et al. Mol Microbiol, 2014 Sep. PMID 25060668, Free PMC Article
  3. Homology modeling of the CheW coupling protein of the chemotaxis signaling complex. Cashman DJ, et al. PLoS One, 2013. PMID 23950985, Free PMC Article
  4. Disruption of chemoreceptor signalling arrays by high levels of CheW, the receptor-kinase coupling protein. Cardozo MJ, et al. Mol Microbiol, 2010 Mar. PMID 20487303, Free PMC Article
  5. Protein footprinting in a complex milieu: identifying the interaction surfaces of the chemotaxis adaptor protein CheW. Underbakke ES, et al. J Mol Biol, 2011 Jun 17. PMID 21463637, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Engineered chemotaxis core signaling units indicate a constrained kinase-off state.
    Title: Engineered chemotaxis core signaling units indicate a constrained kinase-off state.
  2. CheW truncated variants are able to drive chemotaxis behavior through activation and control of the CheA kinase. CheA control and networking activities reside in separate domains of CheW protein.
    Title: Truncated, Non-networking Versions of the Coupling Protein CheW Retain Chemoreceptor Control of Kinase CheA.
  3. the Tar(FO) modules demonstrate that trimerized signaling tips self-associate, bind CheA and CheW, and facilitate conversion of CheA to an active conformation.
    Title: Preformed Soluble Chemoreceptor Trimers That Mimic Cellular Assembly States and Activate CheA Autophosphorylation.
  4. Results suggest that ligand binding triggers changes in the receptor that alter its signalling contacts with CheW.
    Title: Signalling-dependent interactions between the kinase-coupling protein CheW and chemoreceptors in living cells.
  5. Data show that even though static homology models of CheW may be partially structurally different from their corresponding experimentally determined structures, the conformational space they can access through their dynamic variations can be similar.
    Title: Homology modeling of the CheW coupling protein of the chemotaxis signaling complex.
  6. Co-overexpression of Tsr, CheA, and CheW yields hexagonal Arrays.
    Title: New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography.
  7. analysis of CheA and CheW protein architecture and their role in bacterial chemotaxis
    Title: Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins.
  8. The exchange of CheA and CheW at receptor clusters shows a modest dependency on the receptor modification.
    Title: Effects of receptor modification and temperature on dynamics of sensory complexes in Escherichia coli chemotaxis.
  9. Results identified CheW surfaces responsible for CheA-Tsr interaction.
    Title: Protein footprinting in a complex milieu: identifying the interaction surfaces of the chemotaxis adaptor protein CheW.
  10. The 2[to]2[to]1 organization is the core structural and functional unit of chemotaxis signaling complexes and hexagonal arrays characteristic of signaling complexes may be built from this unit.
    Title: Core unit of chemotaxis signaling complexes.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aerotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of post-translational protein modification IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of methyl accepting chemotaxis protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chemotaxis protein CheW

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1972836..1973339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416401.1 chemotaxis protein CheW [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416401.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A418GHT6
    Conserved Domains (1) summary
    PRK10612
    Location:1 → 167
    PRK10612; chemotaxis protein CheW
Nucleotide Protein
Heading Accession and Version

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