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ftnA ferritin iron storage protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946410, updated on 17-Dec-2024

Summary

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Official Symbol
ftnA
Official Full Name
ferritin iron storage protein
Primary source
ECOCYC:EG10921
Locus tag
b1905
See related
ASAP:ABE-0006342
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1904; ftn; gen-165; rsgA
Summary
FtnA helps re-assemble iron-sulfur clusters after oxidative damage (Bitoun, 2008). [More information is available at EcoGene: EG10921]. ftnA encodes the iron-storage protein ferritin, which is similar to human ferritin H . [More information is available at EcoCyc: EG10921].
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Genomic context

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Sequence:
NC_000913.3 (1988716..1989213)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein AzuC Neighboring gene lipoprotein YecR Neighboring gene DUF2492 domain-containing protein YecH Neighboring gene tyrosine:H(+) symporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functionality of the three-site ferroxidase center of Escherichia coli bacterial ferritin (EcFtnA). Bou-Abdallah F, et al. Biochemistry, 2014 Jan 28. PMID 24380371, Free PMC Article
  2. Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria. Kim S, et al. J Mol Biol, 2016 Dec 4. PMID 27777002
  3. Cloning and sequencing of an Escherichia coli K12 gene which encodes a polypeptide having similarity to the human ferritin H subunit. Izuhara M, et al. Mol Gen Genet, 1991 Mar. PMID 2017145
  4. Direct observation of the iron binding sites in a ferritin. Hempstead PD, et al. FEBS Lett, 1994 Aug 22. PMID 8070575
  5. How the presence of three iron binding sites affects the iron storage function of the ferritin (EcFtnA) of Escherichia coli. Treffry A, et al. FEBS Lett, 1998 Aug 7. PMID 9720927

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors show evidence for a short path for iron uptake from His93 on the surface to the ferroxidase center in Helicobacter pylori ferritin and Escherichia coli ferritin.
    Title: Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria.
  2. the data indicate that there are multiple iron-oxidation pathways in EcFtnA with O2 and H2O2 as oxidants.
    Title: Functionality of the three-site ferroxidase center of Escherichia coli bacterial ferritin (EcFtnA).
  3. results show that ftnA iron induction is independent of RyhB and instead involves direct interaction of Fe(2+)-Fur with an 'extended' Fur binding site (containing five tandem Fur boxes) located upstream (-83) of the ftnA promoter.
    Title: Induction of the ferritin gene (ftnA) of Escherichia coli by Fe(2+)-Fur is mediated by reversal of H-NS silencing and is RyhB independent.
  4. E. coli FtnA may act as an iron buffer to sequester the iron released from the disrupted iron-sulfur clusters under oxidative stress conditions and to facilitate the re-assembly of the disrupted iron-sulfur clusters under normal physiological conditions.
    Title: Escherichia coli FtnA acts as an iron buffer for re-assembly of iron-sulfur clusters in response to hydrogen peroxide stress.
  5. N-terminus verified by Edman degradation on complete protein
    Title: Overproduction, purification and characterization of the Escherichia coli ferritin.
  6. isothermal titration calorimetric equations describing a binding model for three classes of independent binding sites are reported here for the first time
    Title: Thermodynamic analysis of ferrous ion binding to Escherichia coli ferritin EcFtnA.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric iron binding IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion sequestering activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to iron ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to iron ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ferritin iron storage protein
NP_416418.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1988716..1989213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416418.1 ferritin iron storage protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416418.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A192C760, A0A979GFQ0, A0AA36KXX4, Q1RAN2
    Conserved Domains (1) summary
    PRK10304
    Location:1 → 165
    PRK10304; non-heme ferritin
Nucleotide Protein
Heading Accession and Version

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