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sdiA DNA-binding transcriptional dual regulator SdiA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946421, updated on 17-Dec-2024

Summary

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Official Symbol
sdiA
Official Full Name
DNA-binding transcriptional dual regulator SdiA
Primary source
ECOCYC:EG10935
Locus tag
b1916
See related
ASAP:ABE-0006381
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1915
Summary
Suppresses inhibitory effect of the MinC/MinD division inhibitor. [More information is available at EcoGene: EG10935]. The SdiA protein belongs to the LuxR/UhpA family of transcriptional regulators and participates in regulating several genes involved in cell division . [More information is available at EcoCyc: EG10935].
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Genomic context

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Sequence:
NC_000913.3 (1996110..1996832, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UvrABC excision nuclease subunit C Neighboring gene DNA-binding transcriptional activator UvrY Neighboring gene protein YecU Neighboring gene DUF2594 domain-containing protein YecF Neighboring gene ncRNA Neighboring gene cystine ABC transporter ATP binding subunit Neighboring gene cystine ABC transporter membrane subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reconfiguring the quorum-sensing regulator SdiA of Escherichia coli to control biofilm formation via indole and N-acylhomoserine lactones. Lee J, et al. Appl Environ Microbiol, 2009 Mar. PMID 19168658, Free PMC Article
  2. N-acyl-L-homoserine lactone signal interception by Escherichia coli. Van Houdt R, et al. FEMS Microbiol Lett, 2006 Mar. PMID 16487323
  3. Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones. Yao Y, et al. J Mol Biol, 2006 Jan 13. PMID 16307757
  4. NMR detection of adventitious xylose binding to the quorum-sensing protein SdiA of Escherichia coli. Yao Y, et al. Bioorg Med Chem Lett, 2007 Nov 15. PMID 17889538, Free PMC Article
  5. Crystallization and preliminary X-ray studies of SdiA from Escherichia coli. Wu C, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Jan 1. PMID 18097094, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Small RNA GadY in Escherichia coli enhances conjugation system of IncP-1 by targeting SdiA.
    Title: Small RNA GadY in Escherichia coli enhances conjugation system of IncP-1 by targeting SdiA.
  2. the characterization of a set of small, regulatory RNAs (sRNAs) expressed from an Escherichia coli locus we have denoted sdsN located adjacent to the LuxR-homolog gene sdiA, is reported.
    Title: Protection against deleterious nitrogen compounds: role of σS-dependent small RNAs encoded adjacent to sdiA.
  3. SdiA interacts with multiple species of effector ligands and its promoter recognition specificity is modulated to various directions depending on the interacting effectors.
    Title: Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets.
  4. Crystal structures of intact SdiA are reported; the E. coli quorum-sensing receptor SdiA seems to bridge both intraspecies and interspecies communication.
    Title: Structural insights into the molecular mechanism of Escherichia coli SdiA, a quorum-sensing receptor.
  5. SdiA does not respond to indole but indole did inhibit N-acyl-l-homoserine lactone sensing by SdiA.
    Title: The acyl homoserine lactone receptor, SdiA, of Escherichia coli and Salmonella enterica serovar Typhimurium does not respond to indole.
  6. CsrA represses translation of sdiA by binding to the coding region of sdiA mRNA.
    Title: CsrA represses translation of sdiA, which encodes the N-acylhomoserine-L-lactone receptor of Escherichia coli, by binding exclusively within the coding region of sdiA mRNA.
  7. roles of SdiA in E. coli (and Salmonella typhimurium): cell division; antibiotic resistance; virulence; biofilms; acid resistance; gene expression regulation; microbial viability [sdiA; quorum-sensing transcriptional activator; [REVIEW]
    Title: Eavesdropping by bacteria: the role of SdiA in Escherichia coli and Salmonella enterica serovar Typhimurium quorum sensing.
  8. Wild-type SdiA decreased biofilm formation by reducing curli production and motility.
    Title: Reconfiguring the quorum-sensing regulator SdiA of Escherichia coli to control biofilm formation via indole and N-acylhomoserine lactones.
  9. NMR analysis of assignments for Escherichia coli SdiA1-171
    Title: Backbone and side chain 1H, 13C and 15N assignments for Escherichia coli SdiA1-171, the autoinducer-binding domain of a quorum sensing protein.
  10. The three-dimensional structure of a complex between the N-terminal domain of SdiA and a candidate autoinducer N-octanoyl-L-homoserine lactone (C8-HSL) has been calculated in solution from NMR data.
    Title: Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator SdiA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1996110..1996832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416426.1 DNA-binding transcriptional dual regulator SdiA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416426.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5C9ARE6
    Conserved Domains (1) summary
    PRK10188
    Location:1 → 240
    PRK10188; transcriptional regulator SdiA
Nucleotide Protein
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