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fliM flagellar motor switch protein FliM [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946442, updated on 3-Dec-2024

Summary

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Official Symbol
fliM
Official Full Name
flagellar motor switch protein FliM
Primary source
ECOCYC:EG10323
Locus tag
b1945
See related
ASAP:ABE-0006469
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cheC2; ECK1943; fla; flaA; flaAII; flaQ; flaQII
Summary
FliGMN switch complex on the rotor of the bacterial flagellum. [More information is available at EcoGene: EG10323]. FliM is one of three components of the flagellar motor's "switch complex. [More information is available at EcoCyc: EG10323].
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Genomic context

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Sequence:
NC_000913.3 (2020087..2021091)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene flagellar biosynthesis protein FliJ Neighboring gene flagellar hook-length control protein Neighboring gene flagellar protein FliL Neighboring gene flagellar motor switch protein FliN Neighboring gene flagellar biosynthesis protein FliO Neighboring gene flagellar biosynthesis protein FliP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a bacterial sensing protein and effects of its elevated expression. Clegg DO, et al. J Bacteriol, 1985 Apr. PMID 2984180, Free PMC Article
  2. Subunit organization and reversal-associated movements in the flagellar switch of Escherichia coli. Sarkar MK, et al. J Biol Chem, 2010 Jan 1. PMID 19858188, Free PMC Article
  3. Structure of the constitutively active double mutant CheYD13K Y106W alone and in complex with a FliM peptide. Dyer CM, et al. J Mol Biol, 2004 Sep 24. PMID 15351654
  4. Binding of the Escherichia coli response regulator CheY to its target measured in vivo by fluorescence resonance energy transfer. Sourjik V, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12232047, Free PMC Article
  5. How 34 pegs fit into 26 + 8 holes in the flagellar motor. Manson MD. J Bacteriol, 2007 Jan. PMID 17085552, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.
    Title: Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.
  2. The results indicate that FliG has a significant tendency to form multimers independently of other flagellar components. The multimerization of FliG is promoted by FliF and also by FliM.
    Title: Biogenesis of the Flagellar Switch Complex in Escherichia coli: Formation of Sub-Complexes Independently of the Basal-Body MS-Ring.
  3. The curve for the pre-adapted flagellar motor with a specific number of FliM units is about a factor of 2 steeper than the measurement in a previous study.
    Title: Ultrasensitivity of an adaptive bacterial motor.
  4. turnover of FliM molecules depends on the presence of active CheY, suggesting a potential role in the process of motor switching
    Title: Signal-dependent turnover of the bacterial flagellar switch protein FliM.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in archaeal or bacterial-type flagellum-dependent cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in bacterial-type flagellum-dependent cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in bacterial-type flagellum-dependent swarming motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bacterial-type flagellum-dependent swimming motility NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in bacterial-type flagellum IEA
Inferred from Electronic Annotation
more info
  
located_in bacterial-type flagellum NAS
Non-traceable Author Statement
more info
 PubMed 
located_in bacterial-type flagellum basal body IEA
Inferred from Electronic Annotation
more info
  
located_in bacterial-type flagellum basal body, C ring NAS
Non-traceable Author Statement
more info
 PubMed 
located_in bacterial-type flagellum rotor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
flagellar motor switch protein FliM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2020087..2021091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416455.1 flagellar motor switch protein FliM [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416455.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2W6QAT1, A0A5B9AIZ2
    Conserved Domains (1) summary
    PRK06666
    Location:1 → 334
    fliM; flagellar motor switch protein FliM; Validated
Nucleotide Protein
Heading Accession and Version

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