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zinT metal-binding protein ZinT [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946480, updated on 3-Dec-2024

Summary

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Official Symbol
zinT
Official Full Name
metal-binding protein ZinT
Primary source
ECOCYC:G7061
Locus tag
b1973
See related
ASAP:ABE-0006546
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1969; yodA
Summary
Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG14049]. YodA binds divalent metal ions including cadmium, zinc, and nickel and is proposed to be a generalized stress factor . [More information is available at EcoCyc: G7061].
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Genomic context

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Sequence:
NC_000913.3 (2041375..2042025)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein-L-methionine sulfoxide reductase catalytic subunit MsrP Neighboring gene membrane-bound flavocytochrome MsrQ Neighboring gene putative cytochrome b561 YodB Neighboring gene tRNA-Ser

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary analysis of Escherichia coli YodA. David G, et al. Acta Crystallogr D Biol Crystallogr, 2002 Jul. PMID 12077457
  2. Regulation of yodA encoding a novel cadmium-induced protein in Escherichia coli. Puškarova A, et al. Microbiology (Reading), 2002 Dec. PMID 12480884
  3. Function of a novel cadmium-induced yodA protein in Escherichia coli. Stojnev T, et al. Curr Microbiol, 2007 Aug. PMID 17632755
  4. Enrichment of Escherichia coli proteins by column chromatography on reactive dye columns. Birch RM, et al. Proteomics, 2003 May. PMID 12748954
  5. Severe zinc depletion of Escherichia coli: roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins. Graham AI, et al. J Biol Chem, 2009 Jul 3. PMID 19377097, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. purified ZinT protein possessed a single, high affinity metal-binding site that can accommodate Zn(2+) or Cd(2+)
    Title: Severe zinc depletion of Escherichia coli: roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins.
  2. ZinT plays a role in zinc homeostasis and is required for growth under zinc limited conditions, suggesting that ZinT is either a periplasmic zinc chaperone or is involved in zinc import.
    Title: Zinc dependence of zinT (yodA) mutants and binding of zinc, cadmium and mercury by ZinT.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: The cadmium-stress stimulon of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cadmium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to zinc ion starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within intracellular zinc ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
metal-binding protein ZinT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2041375..2042025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416482.1 metal-binding protein ZinT [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416482.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7L512
    Conserved Domains (1) summary
    PRK10306
    Location:1 → 216
    PRK10306; zinc/cadmium-binding protein; Provisional
Nucleotide Protein
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