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wcaE GDP-Fuc:2/3-O-Ac-alpha-L-Fuc-(1->3)-alpha-D-Glc-PP-Und alpha-(1,4)-fucosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946543, updated on 3-Dec-2024

Summary

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Official Symbol
wcaE
Official Full Name
GDP-Fuc:2/3-O-Ac-alpha-L-Fuc-(1->3)-alpha-D-Glc-PP-Und alpha-(1,4)-fucosyltransferase
Primary source
ECOCYC:G7100
Locus tag
b2055
See related
ASAP:ABE-0006807
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2049
Summary
The ortholog of WcaE in pathogenic Escherichia coli O157:H7 is involved in synthesis of colanic acid . [More information is available at EcoCyc: G7100].
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Genomic context

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Sequence:
NC_000913.3 (2128904..2129650, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene GDP-mannose 4,6-dehydratase Neighboring gene colanic acid biosynthesis acetyltransferase WcaF Neighboring gene colanic acid polymerase Neighboring gene colanic acid biosynthesis galactosyltransferase WcaC Neighboring gene colanic acid biosynthesis acetyltransferase WcaB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insertion mutagenesis of wca reduces acid and heat tolerance of enterohemorrhagic Escherichia coli O157:H7. Mao Y, et al. J Bacteriol, 2001 Jun. PMID 11371548, Free PMC Article
  2. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
  3. Development of a biofilm production-deficient Escherichia coli strain as a host for biotechnological applications. Sung BH, et al. Appl Environ Microbiol, 2006 May. PMID 16672475, Free PMC Article
  4. Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli. Hagiwara D, et al. J Bacteriol, 2003 Oct. PMID 13129944, Free PMC Article
  5. Identification of the Functional Roles of Six Key Proteins in the Biosynthesis of Enterobacteriaceae Colanic Acid. Scott PM, et al. Biochemistry, 2019 Apr 2. PMID 30821147, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within colanic acid biosynthetic process IGC
Inferred from Genomic Context
more info
 PubMed 
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in slime layer polysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GDP-Fuc:2/3-O-Ac-alpha-L-Fuc-(1->3)-alpha-D-Glc-PP-Und alpha-(1,4)-fucosyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2128904..2129650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416559.1 GDP-Fuc:2/3-O-Ac-alpha-L-Fuc-(1->3)-alpha-D-Glc-PP-Und alpha-(1,4)-fucosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416559.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9ANV9
    Conserved Domains (1) summary
    PRK10063
    Location:1 → 248
    PRK10063; colanic acid biosynthesis glycosyltransferase WcaE
Nucleotide Protein
Heading Accession and Version

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