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baeR DNA-binding transcriptional activator BaeR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946605, updated on 3-Dec-2024

Summary

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Official Symbol
baeR
Official Full Name
DNA-binding transcriptional activator BaeR
Primary source
ECOCYC:EG11618
Locus tag
b2079
See related
ASAP:ABE-0006884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2075
Summary
Confers novobiocin and deoxycholate resistance via activation of mdtABCD and acrD transcription. [More information is available at EcoGene: EG11618]. The transcriptional regulatory protein BaeR is part of the two-component BaeS/BaeR signal transduction system . [More information is available at EcoCyc: EG11618].
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Genomic context

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Sequence:
NC_000913.3 (2164276..2164998)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump RND permease subunit MdtC Neighboring gene putative multidrug efflux pump MdtD Neighboring gene sensor histidine kinase BaeS Neighboring gene DUF1508 domain-containing protein YegP Neighboring gene tRNA wobble base hydroxylation protein TrhP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli. Leblanc SK, et al. J Bacteriol, 2011 Jul. PMID 21515766, Free PMC Article
  2. BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress. Hu L, et al. Microb Pathog, 2020 Oct. PMID 32603765
  3. The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli. Zoetendal EG, et al. Appl Environ Microbiol, 2008 Jan. PMID 18039828, Free PMC Article
  4. Involvement of multiple transcription factors for metal-induced spy gene expression in Escherichia coli. Yamamoto K, et al. J Biotechnol, 2008 Jan 20. PMID 17884222
  5. Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system. Nishino K, et al. J Bacteriol, 2005 Mar. PMID 15716448, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress.
    Title: BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress.
  2. The authors hypothesize that the main function of the BaeSR-mediated response is to upregulate efflux pump expression in response to specific envelope-damaging agents.
    Title: Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli.
  3. transcriptomic data identified the global transcription regulators ArcA, CRP, Fis, FNR, Fur, BaeR, CpxR, and IHF as targets and potential CO sensors
    Title: Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators.
  4. To understand the whole picture of BaeSR regulation, a DNA microarray analysis of the effect of BaeR overproduction was performed.
    Title: Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of response to drug IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional activator BaeR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2164276..2164998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416583.1 DNA-binding transcriptional activator BaeR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416583.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QA26, A0A8S0FR97, A0A8S7EDV7
    Conserved Domains (1) summary
    PRK10710
    Location:1 → 240
    PRK10710; DNA-binding transcriptional regulator BaeR; Provisional
Nucleotide Protein
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