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metG methionine--tRNA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946643, updated on 3-Dec-2024

Summary

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Official Symbol
metG
Official Full Name
methionine--tRNA ligase
Primary source
ECOCYC:EG10586
Locus tag
b2114
See related
ASAP:ABE-0006991
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2107
Summary
metG is an essential gene. [More information is available at EcoGene: EG10586]. MetG is a member of the family of aminoacyl tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG10586].
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Genomic context

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Sequence:
NC_000913.3 (2194300..2196333)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2574 domain-containing protein YehE Neighboring gene P-loop NTPase family protein Mrp Neighboring gene PF05406 family protein YehF Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallographic study at 2.5 A resolution of the interaction of methionyl-tRNA synthetase from Escherichia coli with ATP. Brunie S, et al. J Mol Biol, 1990 Nov 20. PMID 2254937
  2. Regulation of methionyl-transfer ribonucleic acid synthetase formation in Escherichia coli and Salmonella typhimurium. Archibold ER, et al. J Bacteriol, 1973 Jun. PMID 4576394, Free PMC Article
  3. The subunit structure of methionyl-tRNA synthetase from Escherichia coli. Koch GL, et al. FEBS Lett, 1974 Mar 15. PMID 4605346
  4. Molecular cloning and primary structure of the Escherichia coli methionyl-tRNA synthetase gene. Dardel F, et al. J Bacteriol, 1984 Dec. PMID 6094501, Free PMC Article
  5. Methionyl-tRNA synthetase from Escherichia coli. Primary structure of the active crystallised tryptic fragment. Barker DG, et al. Eur J Biochem, 1982 Oct. PMID 6756915

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Methionyl-tRNA synthetase from Escherichia coli. Primary structure of the active crystallised tryptic fragment.
  2. Apo-MetRS structure shows a preference for binding methionine compared with the 19 other natural amino acids.
    Title: Selectivity and specificity of substrate binding in methionyl-tRNA synthetase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methionine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methionine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methionyl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
methionine--tRNA ligase
NP_416617.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2194300..2196333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416617.1 methionine--tRNA ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416617.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3JDZ1
    Conserved Domains (1) summary
    PRK00133
    Location:6 → 677
    metG; methionyl-tRNA synthetase; Reviewed
Nucleotide Protein
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