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pncB nicotinate phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946648, updated on 3-Dec-2024

Summary

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Official Symbol
pncB
Official Full Name
nicotinate phosphoribosyltransferase
Primary source
ECOCYC:EG10742
Locus tag
b0931
See related
ASAP:ABE-0003167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0922
Summary
Nicotinate phosphoribosyltransferase (NAPRTase) mediates the formation of nicotinate mononucleotide from exogenous nicotinate and PRPP. [More information is available at EcoCyc: EG10742].
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Genomic context

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Sequence:
NC_000913.3 (989154..990356, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane porin F Neighboring gene asparagine--tRNA ligase Neighboring gene aminopeptidase N Neighboring gene aliphatic sulfonate ABC transporter ATP binding subunit Neighboring gene aliphatic sulfonate ABC transporter membrane subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defects in RNA polyadenylation impair both lysogenization by and lytic development of Shiga toxin-converting bacteriophages. Nowicki D, et al. J Gen Virol, 2015 Jul. PMID 25711968
  2. Periplasmic localization of nicotinate phosphoribosyltransferase in Escherichia coli. Baecker PA, et al. J Bacteriol, 1978 Mar. PMID 346557, Free PMC Article
  3. Variation of cofactor levels in Escherichia coli. Sequence analysis and expression of the pncB gene encoding nicotinic acid phosphoribosyltransferase. Wubbolts MG, et al. J Biol Chem, 1990 Oct 15. PMID 2211655
  4. Naturally occurring adenines within mRNA coding sequences affect ribosome binding and expression in Escherichia coli. Brock JE, et al. J Bacteriol, 2007 Jan. PMID 17085569, Free PMC Article
  5. Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli. IMSANDE J. J Biol Chem, 1961 May. PMID 13717628

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Significant impairment of lysogenization and lytic development of Shiga toxin-converting (Stx) bacteriophages (Phi24B, 933W, P22, P27 and P32) is demonstrated in host cells with a mutant pcnB gene.
    Title: Defects in RNA polyadenylation impair both lysogenization by and lytic development of Shiga toxin-converting bacteriophages.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Variation of cofactor levels in Escherichia coli. Sequence analysis and expression of the pncB gene encoding nicotinic acid phosphoribosyltransferase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity, forming carbon-nitrogen bonds IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinate phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinate phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within NAD biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nicotinate phosphoribosyltransferase
NP_415451.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    989154..990356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415451.1 nicotinate phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415451.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EC97
    Conserved Domains (1) summary
    PRK05321
    Location:1 → 400
    PRK05321; nicotinate phosphoribosyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version

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