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lysP lysine:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946667, updated on 3-Dec-2024

Summary

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Official Symbol
lysP
Official Full Name
lysine:H(+) symporter
Primary source
ECOCYC:EG11337
Locus tag
b2156
See related
ASAP:ABE-0007131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cadR; ECK2149
Summary
LysP is a negative regulator of cadBA expression in the absence of lysine. [More information is available at EcoGene: EG11337]. LysP is one of two principal systems responsible for the uptake of lysine, the other is the ArgT ABC transporter. [More information is available at EcoCyc: EG11337].
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Genomic context

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Sequence:
NC_000913.3 (2247063..2248532, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene S-formylglutathione hydrolase/S-lactoylglutathione hydrolase Neighboring gene iron-catecholate outer membrane transporter CirA Neighboring gene DNA-binding transcriptional regulator YeiE Neighboring gene PF03601 family inner membrane protein YeiH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Topological analysis of the lysine-specific permease of Escherichia coli. Ellis J, et al. Microbiology (Reading), 1995 Aug. PMID 7551055
  2. Escherichia coli regulatory mutation affecting lysine transport and lysine decarboxylase. Popkin PS, et al. J Bacteriol, 1980 Feb. PMID 6767681, Free PMC Article
  3. Increase in the rate of L-pipecolic acid production using lat-expressing Escherichia coli by lysP and yeiE amplification. Fujii T, et al. Biosci Biotechnol Biochem, 2002 Sep. PMID 12400704
  4. Construction of an Escherichia coli strain unable to synthesize putrescine, spermidine, or cadaverine: characterization of two genes controlling lysine decarboxylase. Tabor H, et al. J Bacteriol, 1980 Dec. PMID 7002915, Free PMC Article
  5. Sequence analysis of TnphoA insertion sites in Vibrio cholerae mutants defective in rugose polysaccharide production. Ali A, et al. Infect Immun, 2000 Dec. PMID 11083805, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upon induction, lysine-dependent conformational changes in LysP transduce the lysine signal via a direct conformational coupling to CadC without resolving the interaction completely.
    Title: New insights into the interplay between the lysine transporter LysP and the pH sensor CadC in Escherichia coli.
  2. These results indicate that ArgP is a major regulator of lysP expression but that Lrp modulates lysP transcription under lysine-limiting conditions.
    Title: Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli.
  3. The results suggest a model according to which CadC is inactivated by an interaction with LysP at a low external lysine concentration.
    Title: The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Topological analysis of the lysine-specific permease of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-lysine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-lysine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to amino acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
lysine:H(+) symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2247063..2248532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416661.1 lysine:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416661.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A478LCZ7
    Conserved Domains (1) summary
    PRK10836
    Location:1 → 489
    PRK10836; lysine transporter; Provisional
Nucleotide Protein
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