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proA glutamate-5-semialdehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946680, updated on 17-Dec-2024

Summary

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Official Symbol
proA
Official Full Name
glutamate-5-semialdehyde dehydrogenase
Primary source
ECOCYC:EG10767
Locus tag
b0243
See related
ASAP:ABE-0000832
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0244; pro(1); pro1
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Genomic context

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Sequence:
NC_000913.3 (261503..262756)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane porin PhoE Neighboring gene glutamate 5-kinase Neighboring gene tRNA-Thr Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Specific action of 4-nitropyridine 1-oxide on Excherichia coli K-12 pro+ strains leading to the isolation of proline-requiring mutants: isolation and characterization of pro-mutants. Inuzuka M, et al. Antimicrob Agents Chemother, 1976 Aug. PMID 791096, Free PMC Article
  2. Structure and biosynthesis of unbranched multicopy single-stranded DNA by reverse transcriptase in a clinical Escherichia coli isolate. Lim D. Mol Microbiol, 1992 Dec. PMID 1282191
  3. The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate -semialdehyde dehydrogenase (NADP), the second enzyme in the pathway. Baich A. Biochim Biophys Acta, 1971 Jul 20. PMID 4399189
  4. Proline biosynthesis in Escherichia coli. Kinetic and mechanistic properties of glutamate semialdehyde dehydrogenase. Hayzer DJ, et al. Biochim Biophys Acta, 1983 Jan 26. PMID 6337636
  5. Proline biosynthesis in Escherichia coli. Stoichiometry and end-product identification of the reaction catalysed by glutamate semialdehyde dehydrogenase. Hayzer DJ, et al. Biochem J, 1981 Aug 1. PMID 7034716, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A synonymous point mutation in the coding region of proB creates a new promoter for proA* and this mutation increases the level of ProA* by 2-fold but increases the growth rate by 5-fold.
    Title: A Synonymous Mutation Upstream of the Gene Encoding a Weak-Link Enzyme Causes an Ultrasensitive Response in Growth Rate.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Analysis of the Escherichia coli proBA locus by DNA and protein sequencing.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-5-semialdehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate-5-semialdehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate-5-semialdehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-proline biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proline biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutamate-5-semialdehyde dehydrogenase
NP_414778.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    261503..262756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414778.1 glutamate-5-semialdehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414778.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MRF9
    Conserved Domains (1) summary
    PRK00197
    Location:1 → 417
    proA; gamma-glutamyl phosphate reductase; Provisional
Nucleotide Protein
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