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ccmB cytochrome c maturation protein B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946692, updated on 3-Dec-2024

Summary

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Official Symbol
ccmB
Official Full Name
cytochrome c maturation protein B
Primary source
ECOCYC:EG12058
Locus tag
b2200
See related
ASAP:ABE-0007277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2192; yejV
Summary
CcmB is an integral membrane component of the CcmABC protoheme IX ABC transporter. [More information is available at EcoCyc: EG12058].
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Genomic context

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Sequence:
NC_000913.3 (2296362..2297024, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene holocytochrome c synthase CcmF component Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein C Neighboring gene cytochrome c maturation protein A Neighboring gene periplasmic nitrate reductase cytochrome c protein Neighboring gene periplasmic nitrate reductase cytochrome c550 protein Neighboring gene ferredoxin-type protein NapH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transmembrane heme delivery systems. Goldman BS, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560218, Free PMC Article
  2. Cytochrome c maturation: a complex pathway for a simple task? Thöny-Meyer L. Biochem Soc Trans, 2002 Aug. PMID 12196152
  3. Axial coordination of heme in ferric CcmE chaperone characterized by EPR spectroscopy. García-Rubio I, et al. Biophys J, 2007 Feb 15. PMID 17142277, Free PMC Article
  4. Evolutionary origins of members of a superfamily of integral membrane cytochrome c biogenesis proteins. Lee JH, et al. Biochim Biophys Acta, 2007 Sep. PMID 17706591
  5. Dynamic features of a heme delivery system for cytochrome C maturation. Ahuja U, et al. J Biol Chem, 2003 Dec 26. PMID 14532274

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role for CcmAB is suggested in the handling of heme by CcmE, which is chemically complex and involves an unusual histidine-heme covalent bond.
    Title: Loss of ATP hydrolysis activity by CcmAB results in loss of c-type cytochrome synthesis and incomplete processing of CcmE.
  2. Expression of CcmB facilitates formation of the CcmA2B1C1 complex and ATP-dependent release of holoCcmE.
    Title: ABC transporter-mediated release of a haem chaperone allows cytochrome c biogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables heme transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytochrome c biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytochrome c biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytochrome c biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytochrome complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cytochrome complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heme import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heme transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c maturation protein B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2296362..2297024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416704.1 cytochrome c maturation protein B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416704.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A2XWW8, A0A8S7ECX4
    Conserved Domains (1) summary
    TIGR01190
    Location:6 → 216
    ccmB; heme exporter protein CcmB
Nucleotide Protein
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