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mqo malate:quinone oxidoreductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946702, updated on 3-Dec-2024

Summary

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Official Symbol
mqo
Official Full Name
malate:quinone oxidoreductase
Primary source
ECOCYC:EG12069
Locus tag
b2210
See related
ASAP:ABE-0007300
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2202; yojH
Summary
MQO activity is regulated by ArcA-ArcB regulatory system, carbon catabolite and growth phase (expressed in exponential phase with rapid degredation in stationary phase). [More information is available at EcoGene: EG12069]. The mqo-encoded malate:quinone oxidoreductase (MQO) is membrane-associated and catalyzes the essentially irreversible oxidation of malate to oxaloacetate . [More information is available at EcoCyc: EG12069].
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Genomic context

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Sequence:
NC_000913.3 (2305108..2306754, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YojO Neighboring gene serine protease inhibitor ecotin Neighboring gene ABC transporter family protein/microcin J25 efflux protein Neighboring gene DNA oxidative demethylase Neighboring gene DNA-binding transcriptional dual regulator/DNA repair protein Ada

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase. Kather B, et al. J Bacteriol, 2000 Jun. PMID 10809701, Free PMC Article
  2. Characteristics and regulation of a phospholipid-activated malate oxidase from Escherichia coli. Narindrasorasak S, et al. J Biol Chem, 1979 Mar 10. PMID 368072
  3. An unusual type of regulation of malate oxidase synthesis in Escherichia coli. Goldie AH, et al. Biochem Biophys Res Commun, 1978 Jul 28. PMID 358983
  4. Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. Kobayashi N, et al. J Bacteriol, 2001 Oct. PMID 11544226, Free PMC Article
  5. Probing the adaptive response of Escherichia coli to extracellular Zn(II). Sigdel TK, et al. Biometals, 2006 Oct. PMID 16937252

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-malate dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-malate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
malate:quinone oxidoreductase
NP_416714.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2305108..2306754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416714.1 malate:quinone oxidoreductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416714.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9QQP0
    Conserved Domains (1) summary
    PRK05257
    Location:27 → 520
    PRK05257; malate:quinone oxidoreductase; Validated
Nucleotide Protein
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