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ccmA cytochrome c maturation protein A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946714, updated on 17-Dec-2024

Summary

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Official Symbol
ccmA
Official Full Name
cytochrome c maturation protein A
Primary source
ECOCYC:EG12059
Locus tag
b2201
See related
ASAP:ABE-0007279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2193; yejW
Summary
CcmA is the ATP-binding component of the CcmABC protoheme IX ABC transporter. [More information is available at EcoCyc: EG12059].
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Genomic context

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Sequence:
NC_000913.3 (2297021..2297644, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene holocytochrome c synthase CcmF component Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein C Neighboring gene cytochrome c maturation protein B Neighboring gene periplasmic nitrate reductase cytochrome c protein Neighboring gene periplasmic nitrate reductase cytochrome c550 protein Neighboring gene ferredoxin-type protein NapH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytochrome c maturation: a complex pathway for a simple task? Thöny-Meyer L. Biochem Soc Trans, 2002 Aug. PMID 12196152
  2. Transmembrane heme delivery systems. Goldman BS, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560218, Free PMC Article
  3. Avoidance of the cytochrome c biogenesis system by periplasmic CXXCH motifs. Mavridou DA, et al. Biochem Soc Trans, 2008 Dec. PMID 19021509
  4. Control of DegP-dependent degradation of c-type cytochromes by heme and the cytochrome c maturation system in Escherichia coli. Gao T, et al. J Bacteriol, 2007 Sep. PMID 17616605, Free PMC Article
  5. Axial coordination of heme in ferric CcmE chaperone characterized by EPR spectroscopy. García-Rubio I, et al. Biophys J, 2007 Feb 15. PMID 17142277, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role for CcmAB is suggested in the handling of heme by CcmE, which is chemically complex and involves an unusual histidine-heme covalent bond.
    Title: Loss of ATP hydrolysis activity by CcmAB results in loss of c-type cytochrome synthesis and incomplete processing of CcmE.
  2. Expression of CcmA facilitates formation of the CcmA2B1C1 complex and ATP-dependent release of holoCcmE.
    Title: ABC transporter-mediated release of a haem chaperone allows cytochrome c biogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ABC-type heme transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytochrome c biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytochrome c biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytochrome complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cytochrome complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heme import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c maturation protein A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2297021..2297644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416705.2 cytochrome c maturation protein A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416705.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0C2EIE7, A0A0D8VKH2, A0A0E2L5P7, A0A0L6Y146, A0A2H4TXG0, A0A376FYE5, A0A377EMA5, A0A776L792, A0A7I0L1T2, A0A828U6I4, A0A8H9VNS5, A0A8S7TYD2, A0AAE4X472, A7ZP23, B7UFL4, S1PZA9
    Conserved Domains (1) summary
    PRK13538
    Location:3 → 203
    PRK13538; cytochrome c biogenesis heme-transporting ATPase CcmA
Nucleotide Protein
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