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menC o-succinylbenzoate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946734, updated on 17-Dec-2024

Summary

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Official Symbol
menC
Official Full Name
o-succinylbenzoate synthase
Primary source
ECOCYC:EG11532
Locus tag
b2261
See related
ASAP:ABE-0007473
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2255
Summary
O-succinylbenzoate synthase catalyzes the formation of the first aromatic intermediate of the menaquinone biosynthetic pathway by dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate . [More information is available at EcoCyc: EG11532].
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Genomic context

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Sequence:
NC_000913.3 (2375000..2375962, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene signal transduction protein PmrD Neighboring gene o-succinylbenzoate--CoA ligase Neighboring gene 1,4-dihydroxy-2-naphthoyl-CoA synthase Neighboring gene 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Neighboring gene 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stability for function trade-offs in the enolase superfamily "catalytic module". Nagatani RA, et al. Biochemistry, 2007 Jun 12. PMID 17503785
  2. Menaquinone biosynthesis: mutants of Escherichia coli K-12 requiring 2-succinylbenzoate. Guest JR. J Bacteriol, 1977 Jun. PMID 324971, Free PMC Article
  3. Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate. Thompson TB, et al. Biochemistry, 2000 Sep 5. PMID 10978150
  4. The lesser "burden borne" by o-succinylbenzoate synthase: an "easy" reaction involving a carboxylate carbon acid. Taylor EA, et al. J Am Chem Soc, 2001 Jun 20. PMID 11403626
  5. Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli. Klenchin VA, et al. Biochemistry, 2003 Dec 16. PMID 14661953

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results showed that E. coli K12 carrying a deletion of either the menD, menC or menE gene was unable to reduce selenate.
    Title: Role of menaquinone biosynthesis genes in selenate reduction by Enterobacter cloacae SLD1a-1 and Escherichia coli K12.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables O-succinylbenzoate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydro-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in menaquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in menaquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within menaquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
o-succinylbenzoate synthase
NP_416764.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2375000..2375962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416764.1 o-succinylbenzoate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416764.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2W6QWZ0
    Conserved Domains (1) summary
    COG1441
    Location:1 → 320
    MenC; O-succinylbenzoate synthase [Coenzyme transport and metabolism]
Nucleotide Protein
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