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fumA fumarase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946826, updated on 3-Dec-2024

Summary

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Official Symbol
fumA
Official Full Name
fumarase A
Primary source
ECOCYC:EG10356
Locus tag
b1612
See related
ASAP:ABE-0005392
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1607
Summary
One of three isozymes in Escherichia coli, fumarase A is a Class I fumarase. [More information is available at EcoCyc: EG10356].
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Genomic context

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Sequence:
NC_000913.3 (1686731..1688377, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensory histidine kinase RstB Neighboring gene DNA replication terminus site-binding protein Neighboring gene fumarase C Neighboring gene mannose-6-phosphate isomerase Neighboring gene DUF945 domain-containing protein YdgA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fumarase a from Escherichia coli: purification and characterization as an iron-sulfur cluster containing enzyme. Flint DH, et al. Biochemistry, 1992 Oct 27. PMID 1329945
  2. High growth rate downregulates fumA mRNA transcription but is dramatically compensated by its mRNA stability in Escherichia coli. Lin HH, et al. Curr Microbiol, 2012 May. PMID 22302452
  3. Nucleotide sequence and transcriptional start point of the phosphomannose isomerase gene (manA) of Escherichia coli. Miles JS, et al. Gene, 1984 Dec. PMID 6397402
  4. Regulatory role of cAMP receptor protein over Escherichia coli fumarase genes. Chen YP, et al. J Microbiol, 2012 Jun. PMID 22752906
  5. Escherichia coli di-iron YtfE protein is necessary for the repair of stress-damaged iron-sulfur clusters. Justino MC, et al. J Biol Chem, 2007 Apr 6. PMID 17289666

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results show that Crp is an activator of fumA and fumC gene expression under various oxygen conditions and growth rates.
    Title: Regulatory role of cAMP receptor protein over Escherichia coli fumarase genes.
  2. The half-life of fumA mRNA was increased by fivefold when the growth rate was increased to 0.96/h.
    Title: High growth rate downregulates fumA mRNA transcription but is dramatically compensated by its mRNA stability in Escherichia coli.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables fumarate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fumarate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fumarate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables fumarate hydratase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxaloacetate tautomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxaloacetate tautomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in generation of precursor metabolites and energy IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fumarase A
NP_416129.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1686731..1688377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416129.1 fumarase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416129.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M7B2
    Conserved Domains (1) summary
    PRK15389
    Location:2 → 537
    PRK15389; fumarate hydratase; Provisional
Nucleotide Protein
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