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fliZ DNA-binding transcriptional regulator FliZ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946833, updated on 3-Dec-2024

Summary

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Official Symbol
fliZ
Official Full Name
DNA-binding transcriptional regulator FliZ
Primary source
ECOCYC:EG11356
Locus tag
b1921
See related
ASAP:ABE-0006394
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1920; yedH
Summary
FliZ antagonizes Crl activation of a subset of RpoS-dependent promoters, without changing RpoS levels, and thus resembles an anti-sigma factor at Crl-stimulated RpoS promoters (Pesavento, 2008). [More information is available at EcoGene: EG11356]. FliZ is an inhibitor of curli expression by reducing the expression of MlrA, YdaM, and YciR. [More information is available at EcoCyc: EG11356].
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Genomic context

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Sequence:
NC_000913.3 (2000473..2001024, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-cysteine desulfhydrase Neighboring gene cystine ABC transporter periplasmic binding protein Neighboring gene RNA polymerase sigma factor FliA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The global repressor FliZ antagonizes gene expression by σS-containing RNA polymerase due to overlapping DNA binding specificity. Pesavento C, et al. Nucleic Acids Res, 2012 Jun. PMID 22323519, Free PMC Article
  2. An alternative sigma factor controls transcription of flagellar class-III operons in Escherichia coli: gene sequence, overproduction, purification and characterization. Liu X, et al. Gene, 1995 Oct 16. PMID 7590326
  3. σ(N) -dependent control of acid resistance and the locus of enterocyte effacement in enterohemorrhagic Escherichia coli is activated by acetyl phosphate in a manner requiring flagellar regulator FlhDC and the σ(S) antagonist FliZ. Mitra A, et al. Microbiologyopen, 2014 Aug. PMID 24931910, Free PMC Article
  4. Escherichia coli fliAZY operon. Mytelka DS, et al. J Bacteriol, 1996 Jan. PMID 8550423, Free PMC Article
  5. Coupling of flagellar gene expression to flagellar assembly in Salmonella enterica serovar typhimurium and Escherichia coli. Chilcott GS, et al. Microbiol Mol Biol Rev, 2000 Dec. PMID 11104815, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of fliZ by NtrC-sigma(N) was shown to be indirect and required an intact flagellar regulator flhDC.
    Title: σ(N) -dependent control of acid resistance and the locus of enterocyte effacement in enterohemorrhagic Escherichia coli is activated by acetyl phosphate in a manner requiring flagellar regulator FlhDC and the σ(S) antagonist FliZ.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sigma factor antagonist activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of bacterial-type flagellum-dependent cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional regulator FliZ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2000473..2001024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416431.2 DNA-binding transcriptional regulator FliZ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416431.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X5R1J0, A0A8S7EJ92
    Conserved Domains (1) summary
    PRK11582
    Location:1 → 168
    PRK11582; flagella biosynthesis regulatory protein FliZ
Nucleotide Protein
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