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emrY tripartite efflux pump membrane subunit EmrY [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946835, updated on 3-Dec-2024

Summary

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Official Symbol
emrY
Official Full Name
tripartite efflux pump membrane subunit EmrY
Primary source
ECOCYC:EG13283
Locus tag
b2367
See related
ASAP:ABE-0007806
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2363
Summary
EvgAS regulon. [More information is available at EcoGene: EG13283]. EmrY is a putative multidrug efflux protein belonging to the major facilitator superfamily (MFS) of transporters . [More information is available at EcoCyc: EG13283].
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Genomic context

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Sequence:
NC_000913.3 (2480638..2482176, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-serine transporter Neighboring gene D-serine ammonia-lyase Neighboring gene tripartite efflux pump membrane fusion protein EmrK Neighboring gene protein EvgL Neighboring gene DNA-binding transcriptional activator EvgA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. May T, et al. Antimicrob Agents Chemother, 2009 Nov. PMID 19721076, Free PMC Article
  2. Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12. Kato A, et al. Biosci Biotechnol Biochem, 2000 Jun. PMID 10923791
  3. Proton-dependent multidrug efflux systems. Paulsen IT, et al. Microbiol Rev, 1996 Dec. PMID 8987357, Free PMC Article
  4. Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters. Nishino K, et al. J Bacteriol, 2001 Feb. PMID 11157960, Free PMC Article
  5. Growth phase-dependent transcription of emrKY, a homolog of multidrug efflux emrAB genes of Escherichia coli, is induced by tetracycline. Tanabe H, et al. J Gen Appl Microbiol, 1997 Oct. PMID 12501312

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bile acid and bile salt transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of efflux pump complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
tripartite efflux pump membrane subunit EmrY

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2480638..2482176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416868.1 tripartite efflux pump membrane subunit EmrY [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416868.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M4M9
    Conserved Domains (1) summary
    NF000391
    Location:10 → 508
    EmrB; multidrug efflux MFS transporter permease subunit EmrB
Nucleotide Protein
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