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pdeA putative c-di-GMP phosphodiesterase PdeA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946864, updated on 3-Dec-2024

Summary

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Official Symbol
pdeA
Official Full Name
putative c-di-GMP phosphodiesterase PdeA
Primary source
ECOCYC:EG11145
Locus tag
b2395
See related
ASAP:ABE-0007899
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2389; yfeA
Summary
YfeA has a central GGDEF putative diguanylate cyclase, then a C-terminal putative cyclic-di-GMP phosphodiesterase EAL domain. [More information is available at EcoGene: EG11145].
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Genomic context

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Sequence:
NC_000913.3 (2515643..2517832, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleoside:H(+) symporter NupC Neighboring gene putative IS186/IS421 transposase Neighboring gene tRNA-Ala Neighboring gene tRNA-Ala

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Reinders A, et al. J Bacteriol, 2016 Feb 1. PMID 26553851, Free PMC Article
  2. Precise mapping and comparison of two evolutionarily related regions of the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an ancestral tRNA operon. Brun YV, et al. J Mol Biol, 1990 Aug 20. PMID 2201776
  3. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609
  4. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833
  5. Characterization of the rdar morphotype, a multicellular behaviour in Enterobacteriaceae. Römling U. Cell Mol Life Sci, 2005 Jun. PMID 15818467, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cyclic-guanylate-specific phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclic-guanylate-specific phosphodiesterase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative c-di-GMP phosphodiesterase PdeA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2515643..2517832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416896.4 putative c-di-GMP phosphodiesterase PdeA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416896.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A830SF13
    Conserved Domains (3) summary
    smart00267
    Location:324 → 473
    GGDEF; diguanylate cyclase
    smart00052
    Location:493 → 729
    EAL; Putative diguanylate phosphodiesterase
    pfam05231
    Location:15 → 311
    MASE1
Nucleotide Protein
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