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murQ N-acetylmuramic acid 6-phosphate etherase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946893, updated on 3-Dec-2024

Summary

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Official Symbol
murQ
Official Full Name
N-acetylmuramic acid 6-phosphate etherase
Primary source
ECOCYC:G7263
Locus tag
b2428
See related
ASAP:ABE-0008007
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2423; yfeU
Summary
A lyase-type cleavage mechanism is proposed for MurQ. [More information is available at EcoGene: EG14162]. MurQ catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid 6-phosphate (MurNAc-6-P), acting in one of the pathways that recycle murein components . [More information is available at EcoCyc: G7263].
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Genomic context

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Sequence:
NC_000913.3 (2545773..2546669)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene oxidoreductase UcpA Neighboring gene DNA-binding transcriptional dual regulator MurR Neighboring gene N-acetylmuramic acid-specific PTS enzyme IICB component/anhydro-N-acetylmuramic acid transporter Neighboring gene penicillin binding protein 4B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling. Hadi T, et al. Biochemistry, 2008 Nov 4. PMID 18837509
  2. The transcriptional factors MurR and catabolite activator protein regulate N-acetylmuramic acid catabolism in Escherichia coli. Jaeger T, et al. J Bacteriol, 2008 Oct. PMID 18723630, Free PMC Article
  3. An alternative route for recycling of N-acetylglucosamine from peptidoglycan involves the N-acetylglucosamine phosphotransferase system in Escherichia coli. Plumbridge J. J Bacteriol, 2009 Sep. PMID 19617367, Free PMC Article
  4. Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite chromatography. Fountoulakis M, et al. Electrophoresis, 1999 Aug. PMID 10493123
  5. Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid. Dahl U, et al. J Bacteriol, 2004 Apr. PMID 15060041, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Putative active site acid/base residues are probed by mutagenesis, and Glu83 and Glu114 are found to be crucial for catalysis.
    Title: Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling.
  2. Escherichia coli MurQ etherase has a role in cleaving the lactyl ether bond of N-acetylmuramic acid
    Title: Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase".
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carbohydrate derivative binding IEA
Inferred from Electronic Annotation
more info
  
enables carbon-oxygen lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbon-oxygen lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbon-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables ether hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ether hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylmuramic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino sugar catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino sugar catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within amino sugar catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino sugar metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan turnover IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan turnover IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan turnover IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
N-acetylmuramic acid 6-phosphate etherase
NP_416923.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2545773..2546669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416923.1 N-acetylmuramic acid 6-phosphate etherase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416923.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A775YWC6
    Conserved Domains (1) summary
    TIGR00274
    Location:6 → 296
    TIGR00274; N-acetylmuramic acid 6-phosphate etherase
Nucleotide Protein
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