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nupC nucleoside:H(+) symporter NupC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946895, updated on 3-Dec-2024

Summary

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Official Symbol
nupC
Official Full Name
nucleoside:H(+) symporter NupC
Primary source
ECOCYC:EG11971
Locus tag
b2393
See related
ASAP:ABE-0007893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cru; ECK2388
Summary
CytR regulon. nupC, nupX, and yegT are paralogs. [More information is available at EcoGene: EG11971]. NupC is one of two high-affinity nucleoside transporters in Escherichia coli. [More information is available at EcoCyc: EG11971].
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Genomic context

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Sequence:
NC_000913.3 (2513042..2514244)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2502 domain-containing protein YpeC Neighboring gene Mn(2(+))/Fe(2(+)): H(+) symporter MntH Neighboring gene protein YpeD Neighboring gene putative IS186/IS421 transposase Neighboring gene putative c-di-GMP phosphodiesterase PdeA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Location of the nupC gene on the physical map of Escherichia coli K-12. Zhang Y, et al. J Bacteriol, 1992 Sep. PMID 1512211, Free PMC Article
  2. A showdomycin-resistant mutant of Escherichia coli K-12 with altered nucleoside transport character. Komatsu Y, et al. Biochim Biophys Acta, 1972 Nov 2. PMID 4563236
  3. Nucleoside transport in cells and membrane vesicles from Escherichia coli K12. Munch-Petersen A, et al. J Biol Chem, 1979 May 25. PMID 374403
  4. Deoxycytidine uptake by isolated membrane vesicles from Escherichia coli K 12. Komatsu Y, et al. Biochim Biophys Acta, 1973 Jul 18. PMID 4354132
  5. Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes. Loewen SK, et al. Mol Membr Biol, 2004 Jan-Feb. PMID 14668133

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cytidine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytidine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uridine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytidine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleoside transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uridine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleoside:H(+) symporter NupC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2513042..2514244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416894.1 nucleoside:H(+) symporter NupC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416894.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376WY91, A0A779ZD29
    Conserved Domains (1) summary
    COG1972
    Location:4 → 400
    NupC; Nucleoside permease NupC [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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