U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

queC 7-cyano-7-deazaguanine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947034, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
queC
Official Full Name
7-cyano-7-deazaguanine synthase
Primary source
ECOCYC:G6245
Locus tag
b0444
See related
ASAP:ABE-0001539
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0438; ybaX
Summary
Asn, Asp, Tyr, and His tRNA anticodons are modified. [More information is available at EcoGene: EG13252]. QueC catalyzes an early step of queuosine biosynthesis, in the step(s) leading from GTP to the formation of preQ0 . [More information is available at EcoCyc: G6245].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (464852..465547, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene helix-hairpin-helix 3 family protein Neighboring gene long-chain acyl-CoA thioesterase FadM Neighboring gene uncharacterized protein YbaE Neighboring gene HMP-PP phosphatase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Targeting QseC signaling and virulence for antibiotic development. Rasko DA, et al. Science, 2008 Aug 22. PMID 18719281, Free PMC Article
  2. An unexpected absence of queuosine modification in the tRNAs of an Escherichia coli B strain. Dineshkumar TK, et al. Microbiology (Reading), 2002 Dec. PMID 12480882
  3. Possible anticodon sequences of tRNA His , tRNA Asm , and tRNA Asp from Escherichia coli B. Universal presence of nucleoside Q in the first postion of the anticondons of these transfer ribonucleic acids. Harada F, et al. Biochemistry, 1972 Jan 18. PMID 4550561
  4. Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. Kasai H, et al. Biochemistry, 1975 Sep 23. PMID 1101947
  5. Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA. Yokoyama S, et al. Nature, 1979 Nov 1. PMID 388227

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. genetic analysis to identify queC (ybaX) as a new member of the queuosine biosynthetic pathway whose gene product is essential in biosynthesis of preQ0
    Title: Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity, forming carbon-nitrogen bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within queuosine biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in queuosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
7-cyano-7-deazaguanine synthase
NP_414978.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    464852..465547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414978.1 7-cyano-7-deazaguanine synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414978.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7BH25
    Conserved Domains (1) summary
    PRK11106
    Location:1 → 231
    PRK11106; queuosine biosynthesis protein QueC; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.