nadK NAD kinase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: nadK
Official Full Name: NAD kinase
Primary source: ECOCYC:EG12192
Locus tag: b2615
See related: ASAP:ABE-0008603
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2611; yfjB; yfjE
Summary: nadK is probably an essential gene since mutants could not be obtained. [More information is available at EcoGene: EG12192]. NAD kinase appears to be an allosteric enzyme, with activity tightly coupled to the NADPH/NADP+ and NADH/NAD+ ratios present in the cell. [More information is available at EcoCyc: EG12192].
NEW: Try the new Gene table
Try the new Transcript table

NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Overexpressing NAD kinase have a negative effect on cell growth in the absence of poly(3-hydroxybutyrate) synthesis.
Title: Overexpression of NAD kinase in recombinant Escherichia coli harboring the phbCAB operon improves poly(3-hydroxybutyrate) production.
N-terminus verified by Edman degradation on complete protein
Title: Molecular characterization of Escherichia coli NAD kinase.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NAD+ kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD metabolic process	IEA Inferred from Electronic Annotation more info
involved_in NADP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within NADP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NADP biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_417105.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain