U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tag 3-methyl-adenine DNA glycosylase I, constitutive [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947137, updated on 17-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
tag
Official Full Name
3-methyl-adenine DNA glycosylase I, constitutive
Primary source
ECOCYC:EG10986
Locus tag
b3549
See related
ASAP:ABE-0011593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3536; tagA
Summary
Tag is constitutively expressed. [More information is available at EcoGene: EG10986]. Alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate (MMS) can produce potentially mutagenic lesions in DNA. [More information is available at EcoCyc: EG10986].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (3713092..3713655)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YhjX Neighboring gene putative outer membrane protein YhjY Neighboring gene peptidyl-lysine N-acetyltransferase YiaC Neighboring gene biotin sulfoxide reductase Neighboring gene PF13488 family lipoprotein YiaD

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nucleotide sequence of the tag gene from Escherichia coli. Steinum AL, et al. Nucleic Acids Res, 1986 May 12. PMID 3520491, Free PMC Article
  2. DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG). Metz AH, et al. EMBO J, 2007 May 2. PMID 17410210, Free PMC Article
  3. 3-Methyladenine-DNA glycosylase I from Escherichia coli-computer modeling and supporting experimental evidence. Plochocka D, et al. Biochem Biophys Res Commun, 2000 Feb 24. PMID 10679272
  4. Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli. Sakumi K, et al. J Biol Chem, 1986 Nov 25. PMID 3536912
  5. Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction. Rydberg B, et al. EMBO J, 1982. PMID 7188181, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA-3-methyladenine glycosylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables DNA-3-methyladenine glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA alkylation repair EXP
Inferred from Experiment
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
3-methyl-adenine DNA glycosylase I, constitutive
NP_418005.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3713092..3713655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418005.1 3-methyl-adenine DNA glycosylase I, constitutive [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418005.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAX2K3Y3
    Conserved Domains (1) summary
    PRK10353
    Location:1 → 187
    PRK10353; DNA-3-methyladenine glycosylase I
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.