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lysO L-lysine/thialysine exporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947142, updated on 3-Dec-2024

Summary

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Official Symbol
lysO
Official Full Name
L-lysine/thialysine exporter
Primary source
ECOCYC:G6458
Locus tag
b0874
See related
ASAP:ABE-0002966
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0865; ybjE
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Genomic context

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Sequence:
NC_000913.3 (913958..914857, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADH oxidoreductase Neighboring gene protein S-nitrosylase Neighboring gene water channel AqpZ Neighboring gene DUF2813 domain-containing protein YbjD Neighboring gene DUF535 domain-containing protein YbjX

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Topological analyses of the L-lysine exporter LysO reveal a critical role for a conserved pair of intramembrane solvent-exposed acidic residues. Dubey S, et al. J Biol Chem, 2021 Oct. PMID 34487760, Free PMC Article
  2. Distinct Paths for Basic Amino Acid Export in Escherichia coli: YbjE (LysO) Mediates Export of L-Lysine. Pathania A, et al. J Bacteriol, 2015 Jun 15. PMID 25845847, Free PMC Article
  3. Global topology analysis of the Escherichia coli inner membrane proteome. Daley DO, et al. Science, 2005 May 27. PMID 15919996
  4. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Topological analyses of the L-lysine exporter LysO reveal a critical role for a conserved pair of intramembrane solvent-exposed acidic residues.
    Title: Topological analyses of the L-lysine exporter LysO reveal a critical role for a conserved pair of intramembrane solvent-exposed acidic residues.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-lysine efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lysine efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables L-lysine efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-lysine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-lysine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
L-lysine/thialysine exporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    913958..914857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415395.2 L-lysine/thialysine exporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415395.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7E6D1
    Conserved Domains (1) summary
    COG2431
    Location:1 → 299
    YbjE; Uncharacterized membrane protein YbjE, DUF340 family [Function unknown]
Nucleotide Protein
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