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qseC sensor histidine kinase QseC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947174, updated on 3-Dec-2024

Summary

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Official Symbol
qseC
Official Full Name
sensor histidine kinase QseC
Primary source
ECOCYC:EG12658
Locus tag
b3026
See related
ASAP:ABE-0009938
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3017; ygiY
Summary
Characterized in an EHEC strain, QueC has been shown to respond and bind to AI-3 and AI-3-cross signalling human hormones epinephrine and norepinephrine (Clarke, 2006). [More information is available at EcoGene: EG13027]. QseC is the sensor kinase component of the QseB-QseC two-component system, which is one component of the quorum-sensing regulatory cascade involved in the regulation of flagella and motility genes. [More information is available at EcoCyc: EG12658].
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Genomic context

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Sequence:
NC_000913.3 (3170484..3171833)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor YgiV Neighboring gene BOF family protein YgiW Neighboring gene DNA-binding transcriptional activator QseB Neighboring gene DUF2645 domain-containing inner membrane protein YgiZ Neighboring gene NADPH:quinone oxidoreductase MdaB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. QseC sensor kinase modulates the human microbiota during enterohemorrhagic Escherichia coli O157:H7 infection in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®). Melchior K, et al. Braz J Microbiol, 2023 Mar. PMID 36469301, Free PMC Article
  2. Human microbiota modulation via QseC sensor kinase mediated in the Escherichia coli O104:H4 outbreak strain infection in microbiome model. Machado Ribeiro TR, et al. BMC Microbiol, 2021 Jun 2. PMID 34078285, Free PMC Article
  3. Structure of the cytoplasmic segment of histidine kinase receptor QseC, a key player in bacterial virulence. Xie W, et al. Protein Pept Lett, 2010 Nov. PMID 20594156, Free PMC Article
  4. Roles of qseC mutation in bacterial resistance against anti-lipopolysaccharide factor isoform 3 (ALFPm3). Khunsri I, et al. PLoS One, 2023. PMID 37267395, Free PMC Article
  5. The QseC sensor kinase: a bacterial adrenergic receptor. Clarke MB, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16803956, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles of qseC mutation in bacterial resistance against anti-lipopolysaccharide factor isoform 3 (ALFPm3).
    Title: Roles of qseC mutation in bacterial resistance against anti-lipopolysaccharide factor isoform 3 (ALFPm3).
  2. QseC sensor kinase modulates the human microbiota during enterohemorrhagic Escherichia coli O157:H7 infection in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME(R)).
    Title: QseC sensor kinase modulates the human microbiota during enterohemorrhagic Escherichia coli O157:H7 infection in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®).
  3. Human microbiota modulation via QseC sensor kinase mediated in the Escherichia coli O104:H4 outbreak strain infection in microbiome model.
    Title: Human microbiota modulation via QseC sensor kinase mediated in the Escherichia coli O104:H4 outbreak strain infection in microbiome model.
  4. The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility.
    Title: The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility.
  5. study concludes that cross talk between the regulatory systems for virulence and metabolism of aromatic amines may depend upon the ability of QseBC and, to a lesser extent QseF, to regulate feaR as well as genes directly involved in virulence
    Title: Conversion of Norepinephrine to 3,4-Dihdroxymandelic Acid in Escherichia coli Requires the QseBC Quorum-Sensing System and the FeaR Transcription Factor.
  6. All components of the QseBC and PmrAB two-component systems (TCSs) are required for proper response to ferric iron.
    Title: Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli.
  7. The presence of one sensor kinase, QseC, is required to regulate the interaction between the other sensor kinase, PmrB and the response regulators from both systems, QseB and PmrA, effectively creating a "four-component" system required for virulence.
    Title: The Histidine Residue of QseC Is Required for Canonical Signaling between QseB and PmrB in Uropathogenic Escherichia coli.
  8. Near-parental level of motility, ability to respond to norepinephrine, and enhanced expression of locus of enterocyte effacement and curli genes might in part be responsible for increased colonization and fecal shedding of the qseBC mutant in calves.
    Title: Escherichia coli O157:H7 lacking the qseBC-encoded quorum-sensing system outcompetes the parental strain in colonization of cattle intestines.
  9. Structural study of the cytoplasmic domain of QseC (QseC-CD) using X-ray crystallography.
    Title: Structure of the cytoplasmic segment of histidine kinase receptor QseC, a key player in bacterial virulence.
  10. The ArcB and QseC transmembrane (TM) domains are both two-helical motifs, whereas the KdpD TM domain comprises a four-helical bundle with shorter second and third helices. The interhelical distances reveal weak interactions of all three receptors.
    Title: Membrane domain structures of three classes of histidine kinase receptors by cell-free expression and rapid NMR analysis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables small molecule binding EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
sensor histidine kinase QseC
NP_417498.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3170484..3171833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417498.1 sensor histidine kinase QseC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417498.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ANT8
    Conserved Domains (1) summary
    PRK10337
    Location:1 → 449
    PRK10337; sensor protein QseC; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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