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norR DNA-binding transcriptional dual regulator NorR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947186, updated on 3-Dec-2024

Summary

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Official Symbol
norR
Official Full Name
DNA-binding transcriptional dual regulator NorR
Primary source
ECOCYC:EG12108
Locus tag
b2709
See related
ASAP:ABE-0008904
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2704; ygaA
Summary
AFMB Structural Genomics target Number 27 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG12108]. NorR, "NO reduction and detoxification regulator," regulates transcription of genes involved in detoxifying nitric oxide (NO) under anaerobic conditions . [More information is available at EcoCyc: EG12108].
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Genomic context

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Sequence:
NC_000913.3 (2830775..2832289, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator GutM Neighboring gene DNA-binding transcriptional repressor SrlR Neighboring gene D-arabinose 5-phosphate isomerase GutQ Neighboring gene anaerobic nitric oxide reductase flavorubredoxin Neighboring gene NADH:flavorubredoxin reductase Neighboring gene carbamoyl--[HypE] ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A DNA region recognized by the nitric oxide-responsive transcriptional activator NorR is conserved in beta- and gamma-proteobacteria. Büsch A, et al. J Bacteriol, 2004 Dec. PMID 15547270, Free PMC Article
  2. DNA binding properties of the Escherichia coli nitric oxide sensor NorR: towards an understanding of the regulation of flavorubredoxin expression. Tucker N, et al. Biochem Soc Trans, 2005 Feb. PMID 15667300
  3. Binding of NorR to three DNA sites is essential for promoter activation of the flavorubredoxin gene, the nitric oxide reductase of Escherichia coli. Justino MC, et al. Biochem Biophys Res Commun, 2005 Mar 11. PMID 15694381
  4. Analysis of the nitric oxide-sensing non-heme iron center in the NorR regulatory protein. Tucker NP, et al. J Biol Chem, 2008 Jan 11. PMID 18003617
  5. Regulators of bacterial responses to nitric oxide. Spiro S. FEMS Microbiol Rev, 2007 Mar. PMID 17313521

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These observations suggest a novel mechanism for negative regulation in bacterial enhancer binding proteins such as NorR in which the GAF domain targets the sigma(54)-interaction surface to prevent access of the AAA+ domain to the sigma factor.
    Title: Nitric oxide-responsive interdomain regulation targets the σ54-interaction surface in the enhancer binding protein NorR.
  2. Analysis of the interaction of NO with the nonheme iron center and determination of the NO-binding affinity constant.
    Title: Characterization of the nitric oxide-reactive transcriptional activator NorR.
  3. the regulatory domain of NorR contains a mononuclear non-haem iron centre, which reversibly binds NO; binding of NO stimulates the ATPase activity of NorR, enabling the activation of transcription by RNA polymerase
    Title: A non-haem iron centre in the transcription factor NorR senses nitric oxide.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nitric oxide binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator NorR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2830775..2832289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417189.2 DNA-binding transcriptional dual regulator NorR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417189.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6PRI9
    Conserved Domains (1) summary
    PRK05022
    Location:3 → 504
    PRK05022; nitric oxide reductase transcriptional regulator NorR
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials