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msrB methionine sulfoxide reductase B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947188, updated on 3-Dec-2024

Summary

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Official Symbol
msrB
Official Full Name
methionine sulfoxide reductase B
Primary source
ECOCYC:EG12394
Locus tag
b1778
See related
ASAP:ABE-0005916
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1776; yeaA
Summary
Tightly binds zinc/iron. [More information is available at EcoGene: EG12394]. MsrB exhibits methionine sulfoxide reductase activity (Km of 6.7 mM) and dimethylsulfoxide reductase activity in vitro . [More information is available at EcoCyc: EG12394].
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Genomic context

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Sequence:
NC_000913.3 (1862016..1862429, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative zinc-binding dehydrogenase YdjL Neighboring gene DUF1315 domain-containing protein YeaC Neighboring gene glyceraldehyde-3-phosphate dehydrogenase A Neighboring gene putative aldose 1-epimerase YeaD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insights into the role of the metal binding site in methionine-R-sulfoxide reductases B. Olry A, et al. Protein Sci, 2005 Nov. PMID 16251365, Free PMC Article
  2. Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage. Weissbach H, et al. Biochim Biophys Acta, 2005 Jan 17. PMID 15680228
  3. Nucleotide sequence of the Escherichia coli gap gene. Different evolutionary behavior of the NAD+-binding domain and of the catalytic domain of D-glyceraldehyde-3-phosphate dehydrogenase. Branlant G, et al. Eur J Biochem, 1985 Jul 1. PMID 2990926
  4. Repair of oxidized proteins. Identification of a new methionine sulfoxide reductase. Grimaud R, et al. J Biol Chem, 2001 Dec 28. PMID 11677230
  5. The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species. Skaar EP, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12096194, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-methionine-(R)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-methionine (R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein repair IEA
Inferred from Electronic Annotation
more info
  
involved_in protein repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
methionine sulfoxide reductase B
NP_416292.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1862016..1862429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416292.1 methionine sulfoxide reductase B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416292.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EH69
    Conserved Domains (1) summary
    PRK00222
    Location:1 → 134
    PRK00222; peptide-methionine (R)-S-oxide reductase MsrB
Nucleotide Protein
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