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casA type I-E CRISPR system Cascade subunit CasA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947222, updated on 3-Dec-2024

Summary

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Official Symbol
casA
Official Full Name
type I-E CRISPR system Cascade subunit CasA
Primary source
ECOCYC:G7430
Locus tag
b2760
See related
ASAP:ABE-0009050
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cse1; ECK2755; ygcL
Summary
The Cascade antiviral complex is comprised of CasABCDE and short CRISP RNAs (crRNAs) and requires the predicted helicase YgcB(Cas3) for activity (Brouns , 2008). [More information is available at EcoGene: EG13119]. Transcription is regulated by BaeR, which plays a role in novobiocin and deoxycholate resistance . [More information is available at EcoCyc: G7430].
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Genomic context

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Sequence:
NC_000913.3 (2882630..2884138, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pre-CRISPR RNA endonuclease Neighboring gene type I-E CRISPR system Cascade subunit CasD Neighboring gene type I-E CRISPR system Cascade subunit CasC Neighboring gene type I-E CRISPR system Cascade subunit CasB Neighboring gene CRISPR-associated endonuclease/helicase Cas3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Hochstrasser ML, et al. Proc Natl Acad Sci U S A, 2014 May 6. PMID 24748111, Free PMC Article
  2. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Jackson RN, et al. Science, 2014 Sep 19. PMID 25103409, Free PMC Article
  3. Molecular biology. Secret weapon. Young RF 3rd. Science, 2008 Aug 15. PMID 18703730, Free PMC Article
  4. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. Baranova N, et al. J Bacteriol, 2002 Aug. PMID 12107134, Free PMC Article
  5. Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Mulepati S, et al. Science, 2014 Sep 19. PMID 25123481, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CRISPR-cas system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
type I-E CRISPR system Cascade subunit CasA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2882630..2884138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417240.1 type I-E CRISPR system Cascade subunit CasA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417240.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6BET3
    Conserved Domains (1) summary
    PRK09693
    Location:1 → 489
    PRK09693; Cascade antiviral complex protein; Validated
Nucleotide Protein
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