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casC type I-E CRISPR system Cascade subunit CasC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947224, updated on 3-Dec-2024

Summary

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Official Symbol
casC
Official Full Name
type I-E CRISPR system Cascade subunit CasC
Primary source
ECOCYC:G7428
Locus tag
b2758
See related
ASAP:ABE-0009046
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cas7; cse4; ECK2753; ygcJ
Summary
The Cascade antiviral complex is comprised of CasABCDE and short CRISP RNAs (crRNAs) and requires the predicted helicase YgcB(Cas3) for activity (Brouns , 2008). [More information is available at EcoGene: EG13117]. CasC: [More information is available at EcoCyc: G7428].
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Genomic context

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Sequence:
NC_000913.3 (2881051..2882142, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multifunctional nuclease Cas1 Neighboring gene pre-CRISPR RNA endonuclease Neighboring gene type I-E CRISPR system Cascade subunit CasD Neighboring gene type I-E CRISPR system Cascade subunit CasB Neighboring gene type I-E CRISPR system Cascade subunit CasA Neighboring gene CRISPR-associated endonuclease/helicase Cas3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein. Howard JA, et al. Biochem J, 2011 Oct 1. PMID 21699496
  2. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Jackson RN, et al. Science, 2014 Sep 19. PMID 25103409, Free PMC Article
  3. A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Babu M, et al. Mol Microbiol, 2011 Jan. PMID 21219465, Free PMC Article
  4. Molecular biology. Secret weapon. Young RF 3rd. Science, 2008 Aug 15. PMID 18703730, Free PMC Article
  5. Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Mulepati S, et al. Science, 2014 Sep 19. PMID 25123481, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A complex of CasABCDE ('Cascade') also promotes formation of R-loops, hybrids of RNA base-paired into duplex DNA.
    Title: Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA/RNA hybrid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CRISPR-cas system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
type I-E CRISPR system Cascade subunit CasC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2881051..2882142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417238.1 type I-E CRISPR system Cascade subunit CasC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417238.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8B3MD98
    Conserved Domains (1) summary
    TIGR01869
    Location:3 → 323
    casC_Cse4; CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI
Nucleotide Protein
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