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mazE antitoxin of the MazF-MazE toxin-antitoxin system MazE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947245, updated on 3-Dec-2024

Summary

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Official Symbol
mazE
Official Full Name
antitoxin of the MazF-MazE toxin-antitoxin system MazE
Primary source
ECOCYC:EG10571
Locus tag
b2783
See related
ASAP:ABE-0009122
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chpAI; chpR; ECK2777
Summary
MazE and the MazE-MazF complex bind DNA in the mazEF promoter region. [More information is available at EcoGene: EG10571]. MazE is an antitoxin that counteracts MazF toxin . [More information is available at EcoCyc: EG10571].
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Genomic context

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Sequence:
NC_000913.3 (2911091..2911339, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene CTP synthetase Neighboring gene nucleoside triphosphate pyrophosphohydrolase Neighboring gene endoribonuclease toxin MazF Neighboring gene GDP/GTP pyrophosphokinase Neighboring gene 23S rRNA m(5)U1939 methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE. Kamphuis MB, et al. Proteins, 2007 Apr 1. PMID 17206710
  2. Energetics of structural transitions of the addiction antitoxin MazE: is a programmed bacterial cell death dependent on the intrinsically flexible nature of the antitoxins? Lah J, et al. J Biol Chem, 2005 Apr 29. PMID 15735309
  3. Crystal structure of the intrinsically flexible addiction antidote MazE. Loris R, et al. J Biol Chem, 2003 Jul 25. PMID 12743116
  4. Characterization of dual substrate binding sites in the homodimeric structure of Escherichia coli mRNA interferase MazF. Li GY, et al. J Mol Biol, 2006 Mar 17. PMID 16413577
  5. Bacterial programmed cell death and multicellular behavior in bacteria. Engelberg-Kulka H, et al. PLoS Genet, 2006 Oct. PMID 17069462, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The increase in growth rate heterogeneity is governed by the MazE antitoxin, and tuned by the MazF-dependent mazF mRNA cleavage.
    Title: Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations.
  2. study could not reproduce mazEF mediated programmed cell death
    Title: Escherichia coli MazEF toxin-antitoxin system does not mediate programmed cell death.
  3. The MazE C-terminus plays an important role in the MazF binding, which was found to increase the MazE affinity for the palindromic single site operator.
    Title: Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding.
  4. The mazE and mazF-mediated cell death pathway prevents the effect of DNA damage on membrane depolarization in E. coli.
    Title: Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway.
  5. Deletion of rpoS, the gene encoding sigma(S) from the bacterial chromosome, permitted mazEF-mediated cell death during stationary growth phase.
    Title: The stationary-phase sigma factor sigma(S) is responsible for the resistance of Escherichia coli stationary-phase cells to mazEF-mediated cell death.
  6. our results showed that the mode of action of antibiotics was determined by the ability of E. coli cells to communicate through the signaling molecule Extracellular Death Factor (EDF) participating in mazEF induction.
    Title: The communication factor EDF and the toxin-antitoxin module mazEF determine the mode of action of antibiotics.
  7. study reports that E. coli mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF); structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn
    Title: A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli.
  8. effect of mazEF on the development of bacteriophage P1
    Title: Escherichia coli mazEF-mediated cell death as a defense mechanism that inhibits the spread of phage P1.
  9. analysis of energetics of structural transitions of the addiction antitoxin MazE
    Title: Energetics of structural transitions of the addiction antitoxin MazE: is a programmed bacterial cell death dependent on the intrinsically flexible nature of the antitoxins?
  10. results reported here support the view that the mazEF module mediates cell death and is part of a programmed cell death network
    Title: MazF-mediated cell death in Escherichia coli: a point of no return.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables toxin sequestering activity EXP
Inferred from Experiment
more info
 PubMed 
enables toxin sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables toxin sequestering activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in single-species biofilm formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of toxin-antitoxin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
antitoxin of the MazF-MazE toxin-antitoxin system MazE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2911091..2911339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417263.1 antitoxin of the MazF-MazE toxin-antitoxin system MazE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417263.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377CV50
    Conserved Domains (1) summary
    PRK09798
    Location:1 → 82
    PRK09798; MazF-MazE toxin-antitoxin system antitoxin MazE
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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