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ilvH acetolactate synthase/acetohydroxybutanoate synthase, regulatory subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947267, updated on 3-Dec-2024

Summary

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Official Symbol
ilvH
Official Full Name
acetolactate synthase/acetohydroxybutanoate synthase, regulatory subunit
Primary source
ECOCYC:EG10499
Locus tag
b0078
See related
ASAP:ABE-0000294
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
brnP; ECK0080
Summary
IlvH is the regulatory (small) subunit of acetolactate synthase III; it confers sensitivity to inhibition by valine and is required for full catalytic activity of acetolactate synthase III holoenzyme . [More information is available at EcoCyc: EG10499].
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Genomic context

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Sequence:
NC_000913.3 (87357..87848)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YabR Neighboring gene acetolactate synthase/acetohydroxybutanoate synthase, catalytic subunit Neighboring gene DNA-binding transcriptional dual regulator Cra Neighboring gene DNA-binding transcriptional repressor MraZ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The N-terminal domain of the regulatory subunit is sufficient for complete activation of acetohydroxyacid synthase III from Escherichia coli. Mendel S, et al. J Mol Biol, 2003 Jan 10. PMID 12488095
  2. Structural genes for a newly recognized acetolactate synthase in Escherichia coli K-12. De Felice M, et al. J Bacteriol, 1974 Dec. PMID 4612003, Free PMC Article
  3. Isolation and characterization of subunits of acetohydroxy acid synthase isozyme III and reconstitution of the holoenzyme. Vyazmensky M, et al. Biochemistry, 1996 Aug 13. PMID 8756689
  4. Lrp, a global regulatory protein of Escherichia coli, binds co-operatively to multiple sites and activates transcription of ilvIH. Wang Q, et al. J Mol Biol, 1993 Jan 20. PMID 8429549
  5. Control of ilvIH transcription during amino acid downshift in stringent and relaxed strains of Escherichia coli. Baccigalupi L, et al. FEMS Microbiol Lett, 1995 Aug 15. PMID 7557316

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acetolactate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetolactate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetolactate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetolactate synthase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-valine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-valine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-valine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within isoleucine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in isoleucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetolactate synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
acetolactate synthase/acetohydroxybutanoate synthase, regulatory subunit
NP_414620.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    87357..87848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414620.1 acetolactate synthase/acetohydroxybutanoate synthase, regulatory subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414620.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7T9A2
    Conserved Domains (1) summary
    PRK11895
    Location:1 → 162
    ilvH; acetolactate synthase 3 regulatory subunit; Reviewed
Nucleotide Protein
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