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flhC DNA-binding transcriptional dual regulator FlhC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947280, updated on 3-Dec-2024

Summary

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Official Symbol
flhC
Official Full Name
DNA-binding transcriptional dual regulator FlhC
Primary source
ECOCYC:EG10319
Locus tag
b1891
See related
ASAP:ABE-0006301
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1892; flaI
Summary
FlhDC is a transcriptional activator of the flagellar regulon. [More information is available at EcoCyc: EG10319].
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Genomic context

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Sequence:
NC_000913.3 (1977266..1977844, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene chemotaxis protein CheA Neighboring gene motility protein B Neighboring gene motility protein A Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator FlhD Neighboring gene IS1 family protein InsB Neighboring gene IS1 family protein InsA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Motility-activating mutations upstream of flhDC reduce acid shock survival of Escherichia coli.
    Title: Motility-activating mutations upstream of flhDC reduce acid shock survival of Escherichia coli.
  2. three IS elements, IS1, IS3 and IS5, transpose to multiple upstream sites within a 370 bp region of the flhDC operon control region. The data are consistent with the possibility that appropriate environmental conditions, namely those that permit but hinder flagellar rotation, result in the activation of a mutational pathway that involves IS element insertion upstream of the flhDC operon.
    Title: Environment-directed activation of the Escherichia coliflhDC operon by transposons.
  3. FlhC is part of flagellar regulatory network.
    Title: Comprehensive mapping of the Escherichia coli flagellar regulatory network.
  4. In conclusion, Hha regulates biofilm formation in enterohemorrhagic Escherichia coli O157:H7 by differential regulation of FlhDC and CsgD, the global regulators of motility and curli production, respectively.
    Title: Hha controls Escherichia coli O157:H7 biofilm formation by differential regulation of global transcriptional regulators FlhDC and CsgD.
  5. Authors report that not only integrations of IS insertion sequences into the regulatory region of the flhDC operon, but also a missense mutation in the lrhA gene enhances motility by relieving transcriptional repression of the flhDC operon.
    Title: Mutations upregulating the flhDC operon of Escherichia coli K-12.
  6. CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage.
    Title: CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage.
  7. Study demonstrates that insertion sequence IS5 in Escherichia coli inserts into the upstream region of the flhDC operon in a manner that depends on whether the environment permits motility.
    Title: IS5 inserts upstream of the master motility operon flhDC in a quasi-Lamarckian way.
  8. Physiological experiments were performed and confirmed that FlhC reduced the cell division rate, the amount of biofilm biomass, and pathogenicity in a chicken embryo lethality model.
    Title: Regulation of cell division, biofilm formation, and virulence by FlhC in Escherichia coli O157:H7 grown on meat.
  9. flhDC mutants of Escherichia coli are nonmotile, better colonize in the intestine, and better utilize sugars than wild type bacteria and Entner-Doudoroff pathway mutants.
    Title: Mouse intestine selects nonmotile flhDC mutants of Escherichia coli MG1655 with increased colonizing ability and better utilization of carbon sources.
  10. crystallographic structure of the Escherichia coli FlhDC complex has been solved to 3.0 A resolution
    Title: Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in bacterial-type flagellum organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of bacterial-type flagellum assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of bacterial-type flagellum assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator FlhC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1977266..1977844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416405.1 DNA-binding transcriptional dual regulator FlhC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416405.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377DR14
    Conserved Domains (1) summary
    PRK12722
    Location:1 → 187
    PRK12722; flagellar transcriptional regulator FlhC
Nucleotide Protein
Heading Accession and Version

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