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tcdA tRNA threonylcarbamoyladenosine dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947291, updated on 3-Dec-2024

Summary

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Official Symbol
tcdA
Official Full Name
tRNA threonylcarbamoyladenosine dehydratase
Primary source
ECOCYC:G7456
Locus tag
b2812
See related
ASAP:ABE-0009223
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
csdL; ECK2808; ygdL
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Genomic context

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Sequence:
NC_000913.3 (2945036..2945842, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF903 domain-containing lipoprotein YgdI Neighboring gene cysteine sulfinate desulfinase Neighboring gene sulfur acceptor protein CsdE Neighboring gene membrane-bound lytic murein transglycosylase A Neighboring gene tRNA-Met

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The crystal structure and small-angle X-ray analysis of CsdL/TcdA reveal a new tRNA binding motif in the MoeB/E1 superfamily. López-Estepa M, et al. PLoS One, 2015. PMID 25897750, Free PMC Article
  2. The CsdA cysteine desulphurase promotes Fe/S biogenesis by recruiting Suf components and participates to a new sulphur transfer pathway by recruiting CsdL (ex-YgdL), a ubiquitin-modifying-like protein. Trotter V, et al. Mol Microbiol, 2009 Dec. PMID 20054882
  3. A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification. Miyauchi K, et al. Nat Chem Biol, 2013 Feb. PMID 23242255
  4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
  5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CsdA interacts with CsdE and a newly discovered protein, called CsdL, resembling E1-like proteins found in ubiquitin-like modification systems.
    Title: The CsdA cysteine desulphurase promotes Fe/S biogenesis by recruiting Suf components and participates to a new sulphur transfer pathway by recruiting CsdL (ex-YgdL), a ubiquitin-modifying-like protein.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA threonylcarbamoyladenosine dehydratase IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA threonylcarbamoyladenosine dehydratase IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cyclic threonylcarbamoyladenosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cyclic threonylcarbamoyladenosine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA threonylcarbamoyladenosine dehydratase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2945036..2945842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417292.1 tRNA threonylcarbamoyladenosine dehydratase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417292.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M393
    Conserved Domains (1) summary
    PRK15116
    Location:1 → 268
    PRK15116; sulfur acceptor protein CsdL; Provisional
Nucleotide Protein
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