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amiC N-acetylmuramoyl-L-alanine amidase C [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947293, updated on 3-Dec-2024

Summary

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Official Symbol
amiC
Official Full Name
N-acetylmuramoyl-L-alanine amidase C
Primary source
ECOCYC:G7458
Locus tag
b2817
See related
ASAP:ABE-0009238
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2813; ygdN
Summary
Verified Tat substrate: [More information is available at EcoGene: EG13086]. AmiC is an N-acetylmuramyl-L-alanine amidase, which cleaves the peptide moiety from N-acetylmuramic acid, removing murein crosslinks. [More information is available at EcoCyc: G7458].
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Genomic context

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Sequence:
NC_000913.3 (2947757..2949010, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene tRNA-Met Neighboring gene N-acetylglutamate synthase Neighboring gene exodeoxyribonuclease V subunit RecD Neighboring gene exodeoxyribonuclease V subunit RecB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antitermination of amidase expression in Pseudomonas aeruginosa is controlled by a novel cytoplasmic amide-binding protein. Wilson SA, et al. EMBO J, 1993 Sep. PMID 8253087, Free PMC Article
  2. Oligomerization of the amide sensor protein AmiC by x-ray and neutron scattering and molecular modeling. Chamberlain D, et al. Biochemistry, 1997 Jul 1. PMID 9201949
  3. Proteolytic processing of Escherichia coli twin-arginine signal peptides by LepB. Lüke I, et al. Arch Microbiol, 2009 Dec. PMID 19809807
  4. Visualization of proteins in intact cells with a clonable tag for electron microscopy. Diestra E, et al. J Struct Biol, 2009 Mar. PMID 19114107
  5. Activity of three murein hydrolases during the cell division cycle of Escherichia coli K-12 as measured in toluene-treated cells. Beck BD, et al. J Bacteriol, 1976 Jun. PMID 780345, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Periplasmic amidases AmiC and AmiA, secreted by the twin arginine transport (Tat) pathway, are localized to the cytoplasm in Escherichia coli YqjA and YghB double mutant cells.
    Title: Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylmuramoyl-L-alanine amidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within FtsZ-dependent cytokinesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell division EXP
Inferred from Experiment
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylmuramoyl-L-alanine amidase C
NP_417294.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2947757..2949010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417294.4 N-acetylmuramoyl-L-alanine amidase C [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417294.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9K280
    Conserved Domains (2) summary
    PRK10319
    Location:171 → 409
    PRK10319; N-acetylmuramoyl-L-alanine amidase AmiA
    pfam11741
    Location:39 → 142
    AMIN; AMIN domain
Nucleotide Protein
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