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mutH DNA mismatch repair protein MutH [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947299, updated on 17-Dec-2024

Summary

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Official Symbol
mutH
Official Full Name
DNA mismatch repair protein MutH
Primary source
ECOCYC:EG10624
Locus tag
b2831
See related
ASAP:ABE-0009287
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2827; mutR; prv
Summary
MutH is a dGATC endonuclease in the MutHLS complex, the methyl-directed mismatch repair pathway . [More information is available at EcoCyc: EG10624].
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Genomic context

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Sequence:
NC_000913.3 (2969662..2970351)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA pyrophosphohydrolase Neighboring gene YgdT Neighboring gene PF03741 family inner membrane protein YgdQ Neighboring gene DUF903 domain-containing lipoprotein YgdR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Detection of protein-DNA interaction with a DNA probe: distinction between single-strand and double-strand DNA-protein interaction. Ban C, et al. Nucleic Acids Res, 2004 Jul 25. PMID 15273279, Free PMC Article
  2. Mutational analysis of the MutH protein from Escherichia coli. Loh T, et al. J Biol Chem, 2001 Apr 13. PMID 11124943
  3. Nucleotide sequence of the Escherichia coli mutH gene. Grafstrom RH, et al. Nucleic Acids Res, 1987 Apr 10. PMID 3031619, Free PMC Article
  4. Coupling distant sites in DNA during DNA mismatch repair. Kolodner RD, et al. Proc Natl Acad Sci U S A, 2007 Aug 7. PMID 17664420, Free PMC Article
  5. Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair. Pluciennik A, et al. Proc Natl Acad Sci U S A, 2007 Jul 31. PMID 17620611, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of MutS-, and MutL-dependent activation of MutH and their roles in methyl-directed mismatch repair in vitro
    Title: Involvement of the beta clamp in methyl-directed mismatch repair in vitro.
  2. MutL recruits the Vsr and MutH to sites of DNA damage.
    Title: The Escherichia coli mismatch repair protein MutL recruits the Vsr and MutH endonucleases in response to DNA damage.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Nucleotide sequence of the Escherichia coli mutH gene.
  4. protein-protein interaction analysis between MutL and MutH
    Title: Mapping protein-protein interactions between MutL and MutH by cross-linking.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables T/G mismatch-specific endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in mismatch repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
  
involved_in mismatch repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA recombination NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of mismatch repair complex IC
Inferred by Curator
more info
 PubMed 
part_of mismatch repair complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
DNA mismatch repair protein MutH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2969662..2970351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417308.1 DNA mismatch repair protein MutH [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417308.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0FLT6
    Conserved Domains (1) summary
    PRK05070
    Location:9 → 226
    PRK05070; DNA mismatch repair protein; Provisional
Nucleotide Protein
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