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pyrR DNA-binding transcriptional activator PyrR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947395, updated on 17-Dec-2024

Summary

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Official Symbol
pyrR
Official Full Name
DNA-binding transcriptional activator PyrR
Primary source
ECOCYC:G7244
Locus tag
b2381
See related
ASAP:ABE-0007857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2377; ypdB
Summary
YpdAB may be a cognate two-component system sensor-regulator pair. [More information is available at EcoGene: EG14149]. A mutant containing a deletion of both ypdA and ypdB does not show a significant phenotype when measured by phenotype microarray . [More information is available at EcoCyc: G7244].
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Genomic context

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Sequence:
NC_000913.3 (2500383..2501117)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutamate--pyruvate aminotransferase AlaC Neighboring gene sensor histidine kinase PyrS Neighboring gene putative AraC-type DNA-binding transcriptional regulator YpdC Neighboring gene putative PTS multiphosphoryl transfer protein FryA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulatory roles of pyruvate-sensing two-component system PyrSR (YpdAB) in Escherichia coli K-12. Miyake Y, et al. FEMS Microbiol Lett, 2019 Jan 1. PMID 30624637
  2. A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance. Vilhena C, et al. J Bacteriol, 2018 Jan 1. PMID 29038258, Free PMC Article
  3. Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Hirakawa H, et al. J Bacteriol, 2003 Mar. PMID 12618449, Free PMC Article
  4. Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems. Zhou L, et al. J Bacteriol, 2003 Aug. PMID 12897016, Free PMC Article
  5. Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12. Oshima T, et al. Mol Microbiol, 2002 Oct. PMID 12366850

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. For induction of YpdAB function, the major exometabolite pyruvate in growing E. coli K-12 was identified as the inducer.
    Title: Regulatory roles of pyruvate-sensing two-component system PyrSR (YpdAB) in Escherichia coli K-12.
  2. findings suggest that the BtsS/BtsR and YpdA/YpdB network contributes to a balancing of the physiological state of all cells within a population
    Title: A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
DNA-binding transcriptional activator PyrR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2500383..2501117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416882.1 DNA-binding transcriptional activator PyrR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416882.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AI82
    Conserved Domains (1) summary
    COG3279
    Location:1 → 244
    LytT; DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms]
Nucleotide Protein
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