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scpB methylmalonyl-CoA decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947408, updated on 17-Dec-2024

Summary

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Official Symbol
scpB
Official Full Name
methylmalonyl-CoA decarboxylase
Primary source
ECOCYC:G7516
Locus tag
b2919
See related
ASAP:ABE-0009581
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2915; ygfG
Summary
Part of a four gene operon encoding enzymes converting succinate to propionate. [More information is available at EcoGene: EG12972]. Methylmalonyl-CoA decarboxylase is a biotin-independent enzyme that catalyzes the decarboxylation of methylmalonyl-CoA to propionyl-CoA. [More information is available at EcoCyc: G7516].
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Genomic context

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Sequence:
NC_000913.3 (3063993..3064778)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator ArgP Neighboring gene methylmalonyl-CoA mutase Neighboring gene methylmalonyl-CoA mutase-interacting GTPase YgfD Neighboring gene propionyl-CoA:succinate CoA transferase Neighboring gene putative DNA-binding transcriptional regulator YgfI Neighboring gene DUF541 domain-containing protein YggE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli. Benning MM, et al. Biochemistry, 2000 Apr 25. PMID 10769118
  2. Metabolic engineering of a novel propionate-independent pathway for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in recombinant Salmonella enterica serovar typhimurium. Aldor IS, et al. Appl Environ Microbiol, 2002 Aug. PMID 12147480, Free PMC Article
  3. Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli. Haller T, et al. Biochemistry, 2000 Apr 25. PMID 10769117
  4. Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity. Hamed RB, et al. Cell Mol Life Sci, 2008 Aug. PMID 18470480, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxy-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyl/ethyl malonyl-CoA decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyl/ethyl malonyl-CoA decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
methylmalonyl-CoA decarboxylase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3063993..3064778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417394.4 methylmalonyl-CoA decarboxylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417394.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3JI77, A0A1X3I2Q4, A0A1X3JDG6, C3SVK2
    Conserved Domains (1) summary
    PRK11423
    Location:1 → 261
    PRK11423; methylmalonyl-CoA decarboxylase; Provisional
Nucleotide Protein
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