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pgk phosphoglycerate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947414, updated on 3-Dec-2024

Summary

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Official Symbol
pgk
Official Full Name
phosphoglycerate kinase
Primary source
ECOCYC:EG10703
Locus tag
b2926
See related
ASAP:ABE-0009605
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2922
Summary
HT_Cmplx50_Mem: [More information is available at EcoGene: EG10703]. Phosphoglycerate kinase is one of the proteins induced by anaerobiosis. [More information is available at EcoCyc: EG10703].
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Genomic context

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Sequence:
NC_000913.3 (3071459..3072622, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene small conductance mechanosensitive channel MscS Neighboring gene fructose-bisphosphate aldolase class II Neighboring gene D-erythrose-4-phosphate dehydrogenase Neighboring gene P-loop NTPase domain-containing protein YggC Neighboring gene fumarase E

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glyceraldehyde 3-p dehydrogenase, glycerate 3-P kinase and enolase mutants of Escherichia coli: genetic studies. Irani MH, et al. Mol Gen Genet, 1976 Apr 23. PMID 775311
  2. Isoenzymes of phosphoglycerate kinase: evolutionary conservation of the structure of this glycolytic enzyme. Watson HC, et al. Biochem Soc Trans, 1990 Apr. PMID 2379683
  3. Isolation and characterization of Escherichia coli mutants defective in enzymes of glycolysis. Irani M, et al. Biochem Biophys Res Commun, 1974 Jan. PMID 4595969
  4. Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability. Young TA, et al. J Mol Biol, 2007 May 18. PMID 17397866
  5. Cloning and characterization of the Escherichia coli phosphoglycerate kinase (pgk) gene. Nellemann LJ, et al. Gene, 1989 Apr 15. PMID 2545537

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
  2. Expression of pgk depends upon an RNase E segmentation process.
    Title: Characterization of the molecular mechanisms involved in the differential production of erythrose-4-phosphate dehydrogenase, 3-phosphoglycerate kinase and class II fructose-1,6-bisphosphate aldolase in Escherichia coli.
  3. Data suggest that proteolysis occurs from the globally unfolded state of E. coli phosphoglycerate kinase, but upon unfolding of only the C-domain in the Saccharomyces enzyme, with the N-domain remaining folded and consequently resistant to cleavage.
    Title: Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoglycerate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoglycerate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycolytic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphoglycerate kinase
NP_417401.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3071459..3072622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417401.1 phosphoglycerate kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417401.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7KBH4, A0A895NZM7
    Conserved Domains (1) summary
    PRK00073
    Location:3 → 383
    pgk; phosphoglycerate kinase; Provisional
Nucleotide Protein
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