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nrdR NrdR transcriptional repressor [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947437, updated on 3-Dec-2024

Summary

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Official Symbol
nrdR
Official Full Name
NrdR transcriptional repressor
Primary source
ECOCYC:EG11320
Locus tag
b0413
See related
ASAP:ABE-0001437
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0407; ybaD
Summary
NrdR has been shown to regulate all three Nrd systems and to bind to the predicted NrdR binding sites (Torrents, 2007). [More information is available at EcoGene: EG11320]. NrdR is a zinc finger/ATP cone transcriptional regulatory protein that regulates the expression of several operons encoding ribonucleotide reductases. [More information is available at EcoCyc: EG11320].
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Genomic context

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Sequence:
NC_000913.3 (433002..433451)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleoside-specific channel-forming protein Tsx Neighboring gene putative lipoprotein YajI Neighboring gene fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase Neighboring gene 6,7-dimethyl-8-ribityllumazine synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribonucleotide reductase NrdR as a novel regulator for motility and chemotaxis during adherent-invasive Escherichia coli infection. Dreux N, et al. Infect Immun, 2015 Apr. PMID 25605769, Free PMC Article
  2. NrdR Transcription Regulation: Global Proteome Analysis and Its Role in Escherichia coli Viability and Virulence. Naveen V, et al. PLoS One, 2016. PMID 27275780, Free PMC Article
  3. Cooperative and allosterically controlled nucleotide binding regulates the DNA binding activity of NrdR. McKethan BL, et al. Mol Microbiol, 2013 Oct. PMID 23941567
  4. Regulation of the operon encoding ribonucleotide reductase in Escherichia coli: evidence for both positive and negative control. Tuggle CK, et al. EMBO J, 1986 May. PMID 3013616, Free PMC Article
  5. Regulation of the operon encoding ribonucleotide reductase: role of the negative sites in nrd repression. Tuggle CK, et al. J Bacteriol, 1990 Apr. PMID 2180902, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that elevated expression of NrdR could be a suitable means to retard bacterial growth and virulence, as its elevated expression reduces bacterial fitness and impairs host cell adhesion.
    Title: NrdR Transcription Regulation: Global Proteome Analysis and Its Role in Escherichia coli Viability and Virulence.
  2. Knockout of nrdR gene decreased adherent-invasive Escherichia coli's ability to colonize the gut mucosa of transgenic mice that express human CEACAM6
    Title: Ribonucleotide reductase NrdR as a novel regulator for motility and chemotaxis during adherent-invasive Escherichia coli infection.
  3. A model is proposed in which NrdR selectively binds (deoxy)nucleoside triphosphates, which are hydrolysed to their monophosphate counterparts in order to regulate DNA binding.
    Title: Cooperative and allosterically controlled nucleotide binding regulates the DNA binding activity of NrdR.
  4. Results show that the NrdR/YbaD protein differentially regulates the expression of the three sets of ribonucleotide reductase genes.
    Title: NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
NrdR transcriptional repressor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    433002..433451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414947.1 NrdR transcriptional repressor [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414947.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A8D0
    Conserved Domains (1) summary
    PRK00464
    Location:1 → 147
    nrdR; transcriptional repressor NrdR
Nucleotide Protein
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