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yqgF ribonuclease H-like domain-containing nuclease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947439, updated on 3-Dec-2024

Summary

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Official Symbol
yqgF
Official Full Name
ribonuclease H-like domain-containing nuclease
Primary source
ECOCYC:G7525
Locus tag
b2949
See related
ASAP:ABE-0009672
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2944
Summary
AFMB Structural Genomics target Number 124 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13290]. YqgF is an essential protein broadly conserved in bacteria that shows similarity to nucleases and may act as a Holliday junction resolvase (HJR) , though the monomeric structure suggests YqgF may not be a HJR . [More information is available at EcoCyc: G7525].
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Genomic context

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Sequence:
NC_000913.3 (3093500..3093916)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(3)U1498 methyltransferase Neighboring gene glutathione synthetase Neighboring gene DUF179 domain-containing protein YqgE Neighboring gene Type II/IV secretion system family protein Neighboring gene PLP homeostasis protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel essential gene Involved in 16S rRNA processing in Escherichia coli. Kurata T, et al. J Mol Biol, 2015 Feb 27. PMID 25545592
  2. Determination of the core of a minimal bacterial gene set. Gil R, et al. Microbiol Mol Biol Rev, 2004 Sep. PMID 15353568, Free PMC Article
  3. Backbone 1H, 15N and 13C resonance assignments of YqgF, an Escherichia coli protein of unknown structure and function. Liu D, et al. J Biomol NMR, 2002 Jun. PMID 12153044
  4. Identification of novel essential Escherichia coli genes conserved among pathogenic bacteria. Freiberg C, et al. J Mol Microbiol Biotechnol, 2001 Jul. PMID 11361082
  5. Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli. Kumar A, et al. Cell Rep, 2016 Jan 26. PMID 26774489

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taken together, these results suggest that YqgF is involved in anti-termination at Rho-dependent terminators in vivo.
    Title: Mutations in the essential Escherichia coli gene, yqgF, and their effects on transcription.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response EXP
Inferred from Experiment
more info
 PubMed 
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA 5'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA 5'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA 5'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transcription antitermination EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribonuclease H-like domain-containing nuclease
NP_417424.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3093500..3093916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417424.1 ribonuclease H-like domain-containing nuclease [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417424.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A3BVK8
    Conserved Domains (1) summary
    PRK00109
    Location:1 → 136
    PRK00109; Holliday junction resolvase RuvX
Nucleotide Protein
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