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pdeL DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947459, updated on 3-Dec-2024

Summary

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Official Symbol
pdeL
Official Full Name
DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL
Primary source
ECOCYC:EG11236
Locus tag
b0315
See related
ASAP:ABE-0001086
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0313; yahA
Summary
YahA has a C-terminal EAL domain, however, it lacks the GGDEF motif. [More information is available at EcoGene: EG11236]. Purified YahA exhibits c-di-GMP-specific phosphodiesterase activity. [More information is available at EcoCyc: EG11236].
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Genomic context

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Sequence:
NC_000913.3 (332371..333459)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene choline:H(+) symporter Neighboring gene protein YahV Neighboring gene putative LysR-type DNA-binding transcriptional regulator YahB Neighboring gene uncharacterized protein YahC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger cyclic di-GMP. Sundriyal A, et al. J Biol Chem, 2014 Mar 7. PMID 24451384, Free PMC Article
  2. The flagellar sigma factor FliA regulates adhesion and invasion of Crohn disease-associated Escherichia coli via a cyclic dimeric GMP-dependent pathway. Claret L, et al. J Biol Chem, 2007 Nov 16. PMID 17827157
  3. DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli. Lamark T, et al. Mol Microbiol, 1991 May. PMID 1956285
  4. Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Reinders A, et al. J Bacteriol, 2016 Feb 1. PMID 26553851, Free PMC Article
  5. Systematic search for the Cra-binding promoters using genomic SELEX system. Shimada T, et al. Genes Cells, 2005 Sep. PMID 16115199

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclic-guanylate-specific phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclic-guanylate-specific phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL
NP_414849.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    332371..333459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414849.1 DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414849.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3JLS8
    Conserved Domains (2) summary
    cd06170
    Location:26 → 80
    LuxR_C_like; C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many ...
    smart00052
    Location:110 → 350
    EAL; Putative diguanylate phosphodiesterase
Nucleotide Protein
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