U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mcbA DUF1471 domain-containing protein McbA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947523, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
mcbA
Official Full Name
DUF1471 domain-containing protein McbA
Primary source
ECOCYC:G6415
Locus tag
b0806
See related
ASAP:ABE-0002753
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0795; ybiM
Summary
The first 22 aa are predicted to be a type I signal peptide. [More information is available at EcoGene: EG13318]. McbA (YbiM) is a predicted periplasmic protein and a member of the YhcN family which has nine paralogous proteins in Escherichia coli. [More information is available at EcoCyc: G6415].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (841796..842056, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PKHD-type hydroxylase YbiX Neighboring gene iron catecholate outer membrane transporter Fiu Neighboring gene 23S rRNA m(6)A1618 methyltransferase Neighboring gene moderate conductance mechanosensitive channel YbiO Neighboring gene L-glutamine ABC transporter ATP binding subunit Neighboring gene L-glutamine ABC transporter membrane subunit

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Proton motive force dissipation precludes interaction of microcin J25 with RNA polymerase, but enhances reactive oxygen species overproduction. Dupuy FG, et al. Biochim Biophys Acta, 2009 Oct. PMID 19616604
  2. The C-terminal part of microcin B is crucial for DNA gyrase inhibition and antibiotic uptake by sensitive cells. Shkundina I, et al. J Bacteriol, 2014 May. PMID 24563033, Free PMC Article
  3. Low molecular weight proteins: a challenge for post-genomic research. Rudd KE, et al. Electrophoresis, 1998 Apr. PMID 9588799
  4. Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA). Zhang XS, et al. ISME J, 2008 Jun. PMID 18309357
  5. Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis. McHugh JP, et al. J Biol Chem, 2003 Aug 8. PMID 12746439

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The C-terminal part of McbA is crucial for DNA gyrase inhibition and antibiotic uptake.
    Title: The C-terminal part of microcin B is crucial for DNA gyrase inhibition and antibiotic uptake by sensitive cells.
  2. Data show that the deleterious reactive oxygen species would be produced as a consequence of the minor fraction of MccJ25 that interacts with the bacterial plasma membrane from the periplasmic side.
    Title: Proton motive force dissipation precludes interaction of microcin J25 with RNA polymerase, but enhances reactive oxygen species overproduction.
  3. YncC inhibits colanic acid overproduction and thereby inhibits mucoidy by repressing expression of periplasmic protein YbiM
    Title: Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA).
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within colanic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DUF1471 domain-containing protein McbA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    841796..842056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415327.2 DUF1471 domain-containing protein McbA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415327.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AJZ7
    Conserved Domains (1) summary
    cl11507
    Location:1 → 86
    DUF1471; Protein of unknown function (DUF1471)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.