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hldE fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947548, updated on 17-Dec-2024

Summary

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Official Symbol
hldE
Official Full Name
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase
Primary source
ECOCYC:G7590
Locus tag
b3052
See related
ASAP:ABE-0010015
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3042; gmhC; rfaE; waaE; yqiF
Summary
HldE is a bifunctional protein with an N-terminal ribokinase superfamily domain and a C-terminal cytidylyltransferase superfamily domain; the two domains are genetically separable . [More information is available at EcoCyc: G7590].
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Genomic context

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Sequence:
NC_000913.3 (3195320..3196753, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative toxic peptide IbsD Neighboring gene ncRNA Neighboring gene toxic peptide IbsE Neighboring gene fused glutamine synthetase deadenylase/glutamine synthetase adenylyltransferase Neighboring gene inorganic triphosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HldE Is Important for Virulence Phenotypes in Enterotoxigenic Escherichia coli. Maigaard Hermansen GM, et al. Front Cell Infect Microbiol, 2018. PMID 30131942, Free PMC Article
  2. Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis. McArthur F, et al. J Bacteriol, 2005 Aug. PMID 16030223, Free PMC Article
  3. The rfaC gene of Salmonella typhimurium. Cloning, sequencing, and enzymatic function in heptose transfer to lipopolysaccharide. Sirisena DM, et al. J Biol Chem, 1992 Sep 15. PMID 1527014
  4. Activation of the gab operon in an RpoS-dependent manner by mutations that truncate the inner core of lipopolysaccharide in Escherichia coli. Joloba ML, et al. J Bacteriol, 2004 Dec. PMID 15576807, Free PMC Article
  5. Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli. Kneidinger B, et al. J Bacteriol, 2002 Jan. PMID 11751812, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables heptose 7-phosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heptose 7-phosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heptose 7-phosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables heptose-1-phosphate adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heptose-1-phosphate adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heptose-1-phosphate adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ADP-L-glycero-beta-D-manno-heptose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ADP-L-glycero-beta-D-manno-heptose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide core region biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase
NP_417524.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3195320..3196753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417524.1 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417524.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5C9AJI6
    Conserved Domains (1) summary
    PRK11316
    Location:1 → 473
    PRK11316; bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE
Nucleotide Protein
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