U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

azoR FMN dependent NADH:quinone oxidoreductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947569, updated on 17-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
azoR
Official Full Name
FMN dependent NADH:quinone oxidoreductase
Primary source
ECOCYC:G6731
Locus tag
b1412
See related
ASAP:ABE-0004712
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
acpD; ECK1405
Summary
AzoR was identifed by N-terminal sequencing in an acyl carrier protein phosphodiesterase preparation and mistaken for the acpD gene. [More information is available at EcoGene: EG12695]. The AzoR protein catalyzes the reductive cleavage of azo groups . [More information is available at EcoCyc: G6731].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1482255..1482860, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrolase/methyltransferase domain-containing protein YnbC Neighboring gene phosphatase domain-containing protein YnbD Neighboring gene ATP-dependent 3'->5' RNA helicase HrpA Neighboring gene DUF218 domain-containing protein YdcF

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Escherichia coli azoreductase AzoR Is involved in resistance to thiol-specific stress caused by electrophilic quinones. Liu G, et al. J Bacteriol, 2009 Oct. PMID 19666717, Free PMC Article
  2. Comparison of the effects of NADH- and NADPH-perturbation stresses on the growth of Escherichia coli. Kim S, et al. Curr Microbiol, 2009 Feb. PMID 18953603
  3. Expansion of substrate specificity and catalytic mechanism of azoreductase by X-ray crystallography and site-directed mutagenesis. Ito K, et al. J Biol Chem, 2008 May 16. PMID 18337254
  4. Three-dimensional structure of AzoR from Escherichia coli. An oxidereductase conserved in microorganisms. Ito K, et al. J Biol Chem, 2006 Jul 21. PMID 16684776
  5. Crystallization and preliminary X-ray analysis of AzoR (azoreductase) from Escherichia coli. Ito K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Apr 1. PMID 16511052, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of azoR substrate specificity and catalytic mechanism
    Title: Expansion of substrate specificity and catalytic mechanism of azoreductase by X-ray crystallography and site-directed mutagenesis.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Putative ACP phosphodiesterase gene (acpD) encodes an azoreductase.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables azobenzene reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
FMN dependent NADH:quinone oxidoreductase
NP_415930.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1482255..1482860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415930.1 FMN dependent NADH:quinone oxidoreductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415930.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MXW8
    Conserved Domains (1) summary
    PRK00170
    Location:1 → 201
    PRK00170; azoreductase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.