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holA DNA polymerase III subunit delta [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947573, updated on 3-Dec-2024

Summary

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Official Symbol
holA
Official Full Name
DNA polymerase III subunit delta
Primary source
ECOCYC:EG11412
Locus tag
b0640
See related
ASAP:ABE-0002192
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0633
Summary
Some delta exists independent of the preinitiation complex, possibly playing a role in stripping beta clamps from DNA in the absence of replication initiation . [More information is available at EcoCyc: EG11412].
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Genomic context

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Sequence:
NC_000913.3 (670574..671605, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase Neighboring gene nicotinate-nucleotide adenylyltransferase Neighboring gene lipopolysaccharide assembly protein LptE Neighboring gene leucine--tRNA ligase Neighboring gene DUF1451 domain-containing protein YbeL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme. Carter JR, et al. J Bacteriol, 1992 Nov. PMID 1400251, Free PMC Article
  2. Cost of rNTP/dNTP pool imbalance at the replication fork. Yao NY, et al. Proc Natl Acad Sci U S A, 2013 Aug 6. PMID 23882084, Free PMC Article
  3. Conserved residues in the delta subunit help the E. coli clamp loader, gamma complex, target primer-template DNA for clamp assembly. Chen S, et al. Nucleic Acids Res, 2008 Jun. PMID 18424802, Free PMC Article
  4. A novel assembly mechanism for the DNA polymerase III holoenzyme DnaX complex: association of deltadelta' with DnaX(4) forms DnaX(3)deltadelta'. Pritchard AE, et al. EMBO J, 2000 Dec 1. PMID 11101526, Free PMC Article
  5. A phage-encoded inhibitor of Escherichia coli DNA replication targets the DNA polymerase clamp loader. Yano ST, et al. Mol Microbiol, 2011 Mar. PMID 21205014

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that rNTPs decrease replication fork rate by competing with dNTPs at the active site of the C-family Pol III replicase at a step that does not require correct base-pairing.
    Title: Cost of rNTP/dNTP pool imbalance at the replication fork.
  2. Enterobacteria Gp8 inhibits the DNAP III of Escherichia coli by targeting the delta subunit of the DNAP III clamp loader.
    Title: A phage-encoded inhibitor of Escherichia coli DNA replication targets the DNA polymerase clamp loader.
  3. N-terminus verified by Edman degradation on complete protein
    Title: DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA-templated DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DNA polymerase III complex IEA
Inferred from Electronic Annotation
more info
  
part_of DNA polymerase III complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of DNA polymerase III, clamp loader complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of replisome NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase III subunit delta

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    670574..671605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415173.1 DNA polymerase III subunit delta [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415173.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN3T932
    Conserved Domains (1) summary
    PRK05574
    Location:2 → 334
    holA; DNA polymerase III subunit delta; Reviewed
Nucleotide Protein
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