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ebgA evolved beta-D-galactosidase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947583, updated on 3-Dec-2024

Summary

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Official Symbol
ebgA
Official Full Name
evolved beta-D-galactosidase subunit alpha
Primary source
ECOCYC:EG10252
Locus tag
b3076
See related
ASAP:ABE-0010104
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3066
Summary
Wildtype EbgA can be mutated to hydrolyze lactose. [More information is available at EcoGene: EG10252]. The EbgA-EbgC complex represents the second -D-galactosidase enzyme in Escherichia coli. [More information is available at EcoCyc: EG10252].
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Genomic context

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Sequence:
NC_000913.3 (3222633..3225725)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative tRNA-binding protein YgjH Neighboring gene DNA-binding transcriptional repressor EbgR Neighboring gene DUF386 domain-containing evolved beta-D-galactosidase subunit beta Neighboring gene putative transporter YgjI Neighboring gene protein YgjJ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Experimental evolution of a new enzymatic function. II. Evolution of multiple functions for ebg enzyme in E. coli. Hall BG. Genetics, 1978 Jul. PMID 97169, Free PMC Article
  2. Probable mechanism of enzyme evolution: how did EBG of E. coli originate? Erhan S. Med Hypotheses, 1979 Nov. PMID 119900
  3. Experimental evolution of a new enzymatic function. Kinetic analysis of the ancestral (ebg) and evolved (ebg) enzymes. Hall BG. J Mol Biol, 1976 Oct 15. PMID 794482
  4. High-throughput screening of enzyme libraries: in vitro evolution of a beta-galactosidase by fluorescence-activated sorting of double emulsions. Mastrobattista E, et al. Chem Biol, 2005 Dec. PMID 16356846
  5. Evolution of a new enzymatic function by recombination within a gene. Hall BG, et al. Proc Natl Acad Sci U S A, 1980 Jun. PMID 6774339, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Catalysis by the large subunit of the second beta-galactosidase of Escherichia coli in the absence of the small subunit.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables beta-galactosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lactose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of beta-galactosidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of beta-galactosidase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
evolved beta-D-galactosidase subunit alpha

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3222633..3225725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026199.1 evolved beta-D-galactosidase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026199.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7JR14
    Conserved Domains (1) summary
    PRK10340
    Location:1 → 1021
    ebgA; cryptic beta-D-galactosidase subunit alpha; Reviewed
Nucleotide Protein
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